BACKGROUND: Cross-species transmission of AA amyloidosis between primates and other animals has not been previously reported. METHODS: Eight geriatric squirrel monkeys were intravenously administered chimpanzee, bovine, or chicken amyloid fibrils and simultaneously received inflammatory stimulation. RESULTS: AA amyloid deposition was not detected in any of the monkeys histopathologically or immunohistochemically. CONCLUSIONS: These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.
BACKGROUND: Cross-species transmission of AA amyloidosis between primates and other animals has not been previously reported. METHODS: Eight geriatric squirrel monkeys were intravenously administered chimpanzee, bovine, or chicken amyloid fibrils and simultaneously received inflammatory stimulation. RESULTS: AA amyloid deposition was not detected in any of the monkeys histopathologically or immunohistochemically. CONCLUSIONS: These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.
Authors: Kurt G Schilling; Fang-Cheng Yeh; Vishwesh Nath; Colin Hansen; Owen Williams; Susan Resnick; Adam W Anderson; Bennett A Landman Journal: Magn Reson Imaging Date: 2019-01-22 Impact factor: 2.546
Authors: Kurt G Schilling; Yurui Gao; Matthew Christian; Vaibhav Janve; Iwona Stepniewska; Bennett A Landman; Adam W Anderson Journal: Neuroinformatics Date: 2019-01