Y-X Gao1,2, P Li3,4, C-H Jiang4,5, C Liu4,5, Y Chen4,5, L Chen4,5, H-Z Ruan1,2, Y-Q Gao4,5. 1. Department of Neurobiology, College of Basic Medical Science, Third Military Medical University, Chongqing, China. 2. Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, China. 3. Department of High Altitude Hygiene, College of High Altitude Medicine, Third Military Medical University, Chongqing, China. 4. Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, China. 5. Department of Pathophysiology and High Altitude Physiology, College of High Altitude Medicine, Third Military Medical University, Chongqing, China.
Abstract
BACKGROUND AND PURPOSE: The present study aimed to examine how long-term migration to high-altitude regions affects mentality and cognition, and the correlation with various physiological and biochemical changes. METHODS: The WHO Neurobehavioral Core Test Battery, Raven's Standard Progressive Matrices (RSPM) and Pittsburgh Sleep Quality Index questionnaire were used to assess 141 young male subjects who lived in plain regions and 217 young male subjects who had migrated to a 4500 m high-altitude region and lived there for 1-5 years. Arterial oxyhemoglobin saturation, cerebral tissue oxygenation indices (TOIs), serum S100B and brain-derived neurotrophic factor (BDNF) were also measured. RESULTS: Long-term migrators to a high-altitude region exhibited exacerbated mood disorders, retarded color discrimination ability, decreased visual memory capacity, and impaired perceptual motor skill and motion stability. In addition, the migrators exhibited lower RSPM scores and lower sleep quality. Further analyses revealed significant correlations between sleep quality and cerebral TOIs, mood and sleep quality, mood and certain cognitive functions, mood and serum BDNF levels, and RSPM scores and serum S100B levels. CONCLUSIONS: Long-term living at high altitudes causes significant impairment of psychological and cognitive function. Cerebral hypoxic extent, sleep quality and biochemical dysfunction are major influencing factors.
BACKGROUND AND PURPOSE: The present study aimed to examine how long-term migration to high-altitude regions affects mentality and cognition, and the correlation with various physiological and biochemical changes. METHODS: The WHO Neurobehavioral Core Test Battery, Raven's Standard Progressive Matrices (RSPM) and Pittsburgh Sleep Quality Index questionnaire were used to assess 141 young male subjects who lived in plain regions and 217 young male subjects who had migrated to a 4500 m high-altitude region and lived there for 1-5 years. Arterial oxyhemoglobin saturation, cerebral tissue oxygenation indices (TOIs), serum S100B and brain-derived neurotrophic factor (BDNF) were also measured. RESULTS: Long-term migrators to a high-altitude region exhibited exacerbated mood disorders, retarded color discrimination ability, decreased visual memory capacity, and impaired perceptual motor skill and motion stability. In addition, the migrators exhibited lower RSPM scores and lower sleep quality. Further analyses revealed significant correlations between sleep quality and cerebral TOIs, mood and sleep quality, mood and certain cognitive functions, mood and serum BDNF levels, and RSPM scores and serum S100B levels. CONCLUSIONS: Long-term living at high altitudes causes significant impairment of psychological and cognitive function. Cerebral hypoxic extent, sleep quality and biochemical dysfunction are major influencing factors.
Authors: Gabriella Mk Rossetti; Giovanni d'Avossa; Matthew Rogan; Jamie H Macdonald; Samuel J Oliver; Paul G Mullins Journal: J Cereb Blood Flow Metab Date: 2020-06-14 Impact factor: 6.200
Authors: Erica C Heinrich; Matea A Djokic; Dillon Gilbertson; Pamela N DeYoung; Naa-Oye Bosompra; Lu Wu; Cecilia Anza-Ramirez; Jeremy E Orr; Frank L Powell; Atul Malhotra; Tatum S Simonson Journal: PLoS One Date: 2019-06-12 Impact factor: 3.240