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Literature DB >> 25039764

The Ded1/DDX3 subfamily of DEAD-box RNA helicases.

Abstract

In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast and DDX3 from human form a well-defined subfamily that is characterized by high sequence conservation in their helicase core and their N- and C- termini. Individual members of this Ded1/DDX3 subfamily perform multiple functions in RNA metabolism in both nucleus and cytoplasm. Ded1/DDX3 subfamily members have also been implicated in cellular signaling pathways and are targeted by diverse viruses. In this review, we discuss the considerable body of work on the biochemistry and biology of these proteins, including the recently discovered link of human DDX3 to tumorigenesis.

Entities: Gene Species

Keywords: DDX3; DEAD-box; Ded1; RNA; helicase; tumor; unwinding; virus

Mesh：

Substances：

Year: 2014 PMID： 25039764 DOI： 10.3109/10409238.2014.931339

Source DB: PubMed Journal: Crit Rev Biochem Mol Biol ISSN： 1040-9238 Impact factor: 8.250

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Cited

65 in total

1. DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation.

Authors: Sathya N Thulasi Raman; Guanqun Liu; Hyun Mi Pyo; Ya Cheng Cui; Fang Xu; Lisanework E Ayalew; Suresh K Tikoo; Yan Zhou
Journal: J Virol Date: 2016-01-20 Impact factor: 5.103

Review 2. The DDX5/Dbp2 subfamily of DEAD-box RNA helicases.

Authors: Zheng Xing; Wai Kit Ma; Elizabeth J Tran
Journal: Wiley Interdiscip Rev RNA Date: 2018-12-02 Impact factor: 9.957

3. Unwinding the mechanisms of a DEAD-box RNA helicase in cancer.

Authors: Rick Russell
Journal: J Mol Biol Date: 2015-03-30 Impact factor: 5.469

4. The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.

Authors: Bita Khadivjam; Camille Stegen; Marc-Aurèle Hogue-Racine; Nabil El Bilali; Katinka Döhner; Beate Sodeik; Roger Lippé
Journal: J Virol Date: 2017-03-29 Impact factor: 5.103

5. Gle1 Regulates RNA Binding of the DEAD-Box Helicase Ded1 in Its Complex Role in Translation Initiation.

Authors: Peyman P Aryanpur; Chelsea A Regan; John M Collins; Telsa M Mittelmeier; David M Renner; Ashley M Vergara; Nicolette P Brown; Timothy A Bolger
Journal: Mol Cell Biol Date: 2017-10-13 Impact factor: 4.272

6. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

Authors: Jiexin Wang; Prashant Rajbhandari; Andrey Damianov; Areum Han; Tamer Sallam; Hironori Waki; Claudio J Villanueva; Stephen D Lee; Ronni Nielsen; Susanne Mandrup; Karen Reue; Stephen G Young; Julian Whitelegge; Enrique Saez; Douglas L Black; Peter Tontonoz
Journal: J Clin Invest Date: 2017-02-13 Impact factor: 14.808

The Ded1/DDX3 subfamily of DEAD-box RNA helicases.

1. DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation.

Review 2. The DDX5/Dbp2 subfamily of DEAD-box RNA helicases.

3. Unwinding the mechanisms of a DEAD-box RNA helicase in cancer.

4. The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.

5. Gle1 Regulates RNA Binding of the DEAD-Box Helicase Ded1 in Its Complex Role in Translation Initiation.

6. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

7. DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries.

Review 8. A helicase links upstream ORFs and RNA structure.

9. Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo.

10. Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.