BACKGROUND/AIM: It remains unclear which type of non-surgical treatment is most appropriate as first-line intervention against peri-implantitis. This systematic review and Bayesian network meta-analysis aimed to compare the clinical effect of various non-surgical peri-implantitis therapies. METHODS: The PubMed, SCOPUS, CINAHL, DARE and Web of Knowledge databases were searched in duplicate for randomized controlled trials (RCTs) up to and including 01 January 2014. Additional relevant literature was identified using handsearching of reference lists within published systematic reviews, and screenings of OpenGrey, ClinicalTrials.gov and Controlled-Trials.com. Probing pocket depth (PPD) was the outcome measure assessed. Multilevel mixed modelling was used to perform the network meta-analysis, and Markov Chain Monte Carlo simulation to obtain random effects. RESULTS: Eleven studies were included in the network meta-analysis. Debridement in conjunction with antibiotics achieved the greatest additional PPD reduction in comparison to debridement only (0.490 mm; 95% credible interval: -0.647;1.252). The highest probabilities of being the most effective interventions were achieved by Vector system (p = 20.60%), debridement plus periochip (p = 20.00%) and photodynamic therapy (p = 18.90%). CONCLUSION: The differences between various non-surgical treatments were relatively small with large credible intervals. On the basis of currently available RCTs, there is insufficient evidence to support that any particular non-surgical treatment for peri-implantitis showed better performance than debridement alone.
BACKGROUND/AIM: It remains unclear which type of non-surgical treatment is most appropriate as first-line intervention against peri-implantitis. This systematic review and Bayesian network meta-analysis aimed to compare the clinical effect of various non-surgical peri-implantitis therapies. METHODS: The PubMed, SCOPUS, CINAHL, DARE and Web of Knowledge databases were searched in duplicate for randomized controlled trials (RCTs) up to and including 01 January 2014. Additional relevant literature was identified using handsearching of reference lists within published systematic reviews, and screenings of OpenGrey, ClinicalTrials.gov and Controlled-Trials.com. Probing pocket depth (PPD) was the outcome measure assessed. Multilevel mixed modelling was used to perform the network meta-analysis, and Markov Chain Monte Carlo simulation to obtain random effects. RESULTS: Eleven studies were included in the network meta-analysis. Debridement in conjunction with antibiotics achieved the greatest additional PPD reduction in comparison to debridement only (0.490 mm; 95% credible interval: -0.647;1.252). The highest probabilities of being the most effective interventions were achieved by Vector system (p = 20.60%), debridement plus periochip (p = 20.00%) and photodynamic therapy (p = 18.90%). CONCLUSION: The differences between various non-surgical treatments were relatively small with large credible intervals. On the basis of currently available RCTs, there is insufficient evidence to support that any particular non-surgical treatment for peri-implantitis showed better performance than debridement alone.
Authors: Tassiane Panta Wagner; Paula Rodrigues Pires; Fernando Silva Rios; Joao Augusto Peixoto de Oliveira; Ricardo Dos Santos Araujo Costa; Kelly F Cunha; Heraldo Luis Dias Silveira; Suzana Pimentel; Marcio Zaffalon Casati; Cassiano Kuchenbecker Rosing; Alex Nogueira Haas Journal: Clin Oral Investig Date: 2021-03-16 Impact factor: 3.573
Authors: Mauro Elias Mesko; Brian Hutton; Jovito Adiel Skupien; Rafael Sarkis-Onofre; David Moher; Tatiana Pereira-Cenci Journal: Syst Rev Date: 2017-01-13
Authors: J C Wohlfahrt; B J Evensen; B Zeza; H Jansson; A Pilloni; A M Roos-Jansåker; G L Di Tanna; A M Aass; M Klepp; O C Koldsland Journal: Int J Implant Dent Date: 2017-08-03
Authors: Carla Fons-Badal; Rubén Agustín-Panadero; Carlos Labaig-Rueda; Maria Fernanda Solá-Ruiz; Marina García-Selva; Antonio Fons Font Journal: J Clin Med Date: 2022-07-15 Impact factor: 4.964