| Literature DB >> 25037681 |
Ablajan Turak1, She-Po Shi2, Yong Jiang3, Peng-Fei Tu4.
Abstract
Five dimeric guaianolides, absinthins A-E, and seven known dimeric guaianolides were isolated from Artemisia absinthium. Their structures were elucidated based on 1D- and 2D-NMR experiments, including (1)H NMR, (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOESY, and through HRESIMS data analysis. The absolute configuration of the known compound, anabsinthin, was determined by X-ray crystallographic analysis. The isolated compounds were tested to assess their inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 cells; absinthin C and isoanabsinthin exhibited significant inhibitory effects with IC50 values of 1.52 and 1.98μM, respectively.Entities:
Keywords: Artemisia absinthium; Asteraceae; BV-2 cells; Dimeric guaianolides; Inhibition of NO production; Single-crystal X-ray analysis; Wormwood
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Year: 2014 PMID： 25037681 DOI： 10.1016/j.phytochem.2014.06.016
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072