Meena Nathan1, Lynn A Sleeper2, Richard G Ohye3, Peter C Frommelt4, Christopher A Caldarone5, James S Tweddell4, Minmin Lu6, Gail D Pearson7, J William Gaynor8, Christian Pizarro9, Ismee A Williams10, Steven D Colan11, Carolyn Dunbar-Masterson12, Peter J Gruber13, Kevin Hill14, Jennifer Hirsch-Romano3, Jeffrey P Jacobs15, Jonathan R Kaltman7, S Ram Kumar16, David Morales17, Scott M Bradley18, Kirk Kanter19, Jane W Newburger12. 1. Children's Hospital Boston and Harvard Medical School, Boston, Mass. Electronic address: meena.nathan@cardio.chboston.org. 2. Cytel Inc, Cambridge, Mass. 3. University of Michigan Medical School, Ann Arbor, Mich. 4. Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, Wis. 5. Hospital for Sick Children, Toronto, Ontario, Canada. 6. New England Research Institutes, Watertown, Mass. 7. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. 8. Children's Hospital of Philadelphia and University of Pennsylvania Medical School, Philadelphia, Pa. 9. Nemours Cardiac Center, Wilmington, Del. 10. Morgan Stanley Children's Hospital of NewYork-Presbyterian, New York, NY. 11. Children's Hospital Boston and Harvard Medical School, Boston, Mass; New England Research Institutes, Watertown, Mass. 12. Children's Hospital Boston and Harvard Medical School, Boston, Mass. 13. University of Iowa Carver College of Medicine, Iowa City, Iowa. 14. Duke University, Chapel Hill, NC. 15. Johns Hopkins All Children's Heart Institute, St Petersburg, Fla. 16. Children's Hospital Los Angeles, Los Angeles, Calif. 17. Cincinnati Children's Medical Center, Cincinnati, Ohio. 18. Medical University of South Carolina, Charleston, SC. 19. Emory University, Atlanta, Ga.
Abstract
OBJECTIVES: The technical performance score (TPS) has been reported in a single center study to predict the outcomes after congenital cardiac surgery. We sought to determine the association of the TPS with outcomes in patients undergoing the Norwood procedure in the Single Ventricle Reconstruction trial. METHODS: We calculated the TPS (class 1, optimal; class 2, adequate; class 3, inadequate) according to the predischarge echocardiograms analyzed in a core laboratory and unplanned reinterventions that occurred before discharge from the Norwood hospitalization. Multivariable regression examined the association of the TPS with interval to first extubation, Norwood length of stay, death or transplantation, unplanned postdischarge reinterventions, and neurodevelopment at 14 months old. RESULTS: Of 549 patients undergoing a Norwood procedure, 356 (65%) had an echocardiogram adequate to assess atrial septal restriction or arch obstruction or an unplanned reintervention, enabling calculation of the TPS. On multivariable regression, adjusting for preoperative variables, a better TPS was an independent predictor of a shorter interval to first extubation (P=.019), better transplant-free survival before Norwood discharge (P<.001; odds ratio, 9.1 for inadequate vs optimal), shorter hospital length of stay (P<.001), fewer unplanned reinterventions between Norwood discharge and stage II (P=.004), and a higher Bayley II psychomotor development index at 14 months (P=.031). The TPS was not associated with transplant-free survival after Norwood discharge, unplanned reinterventions after stage II, or the Bayley II mental development index at 14 months. CONCLUSIONS:TPS is an independent predictor of important outcomes after Norwood and could serve as a tool for quality improvement.
RCT Entities:
OBJECTIVES: The technical performance score (TPS) has been reported in a single center study to predict the outcomes after congenital cardiac surgery. We sought to determine the association of the TPS with outcomes in patients undergoing the Norwood procedure in the Single Ventricle Reconstruction trial. METHODS: We calculated the TPS (class 1, optimal; class 2, adequate; class 3, inadequate) according to the predischarge echocardiograms analyzed in a core laboratory and unplanned reinterventions that occurred before discharge from the Norwood hospitalization. Multivariable regression examined the association of the TPS with interval to first extubation, Norwood length of stay, death or transplantation, unplanned postdischarge reinterventions, and neurodevelopment at 14 months old. RESULTS: Of 549 patients undergoing a Norwood procedure, 356 (65%) had an echocardiogram adequate to assess atrial septal restriction or arch obstruction or an unplanned reintervention, enabling calculation of the TPS. On multivariable regression, adjusting for preoperative variables, a better TPS was an independent predictor of a shorter interval to first extubation (P=.019), better transplant-free survival before Norwood discharge (P<.001; odds ratio, 9.1 for inadequate vs optimal), shorter hospital length of stay (P<.001), fewer unplanned reinterventions between Norwood discharge and stage II (P=.004), and a higher Bayley II psychomotor development index at 14 months (P=.031). The TPS was not associated with transplant-free survival after Norwood discharge, unplanned reinterventions after stage II, or the Bayley II mental development index at 14 months. CONCLUSIONS: TPS is an independent predictor of important outcomes after Norwood and could serve as a tool for quality improvement.
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