Slavica Radovanovic1, Ana Savic-Radojevic2, Tatjana Pekmezovic3, Olivera Markovic4, Lidija Memon1, Svetlana Jelic4, Dragan Simic5, Tanja Radic2, Marija Pljesa-Ercegovac2, Tatjana Simic6. 1. Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrade, Serbia. 2. Institut za Medicinsku i Klinicku Biohemiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia. 3. Institut za Epidemiologiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia. 4. Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrade, Serbia; Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia. 5. Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia; Klinika za Kardiovaskularne Bolesti, Klinicki Centar Srbije, Belgrade, Serbia. 6. Institut za Medicinsku i Klinicku Biohemiju, Medicinski Fakultet, Univerzitet u Beogradu, Belgrade, Serbia. Electronic address: tatjanasimic@med.bg.ac.rs.
Abstract
INTRODUCTION AND OBJECTIVES: Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown. METHODS: The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling was addressed in 120 patients with chronic ischemic heart failure. To determine the independent contribution of uric acid and gamma-glutamyl transferase to the flow-mediated dilation and echocardiographic indices of remodeling, a series of multiple linear regression models, based on traditional and nontraditional risk factors impacting upon these parameters, were constructed. RESULTS: Uric acid, but not gamma-glutamyl transferase, was an independent predictor of flow-mediated dilation. Uric acid was associated with all the echocardiographic indices of left ventricular dysfunction tested in 3 multiple-regression models. Uric acid correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.337; r = 0.340; r = 0.321; r = 0.294; P = .001, respectively). Gamma-glutamyl transferase was an independent predictor of left ventricular end-systolic volume and left ventricular end-diastolic volume, after adjustment for all variables. Gamma-glutamyl transferase correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.238, P = .009; r = 0.219, P = .016; r = 0.359, P < .001; r = 0.369, P = .001, respectively). CONCLUSIONS: Serum uric acid and gamma-glutamyl transferase levels are associated with left ventricular remodeling in patients with chronic ischemic heart failure.
INTRODUCTION AND OBJECTIVES:Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown. METHODS: The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling was addressed in 120 patients with chronic ischemic heart failure. To determine the independent contribution of uric acid and gamma-glutamyl transferase to the flow-mediated dilation and echocardiographic indices of remodeling, a series of multiple linear regression models, based on traditional and nontraditional risk factors impacting upon these parameters, were constructed. RESULTS:Uric acid, but not gamma-glutamyl transferase, was an independent predictor of flow-mediated dilation. Uric acid was associated with all the echocardiographic indices of left ventricular dysfunction tested in 3 multiple-regression models. Uric acid correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.337; r = 0.340; r = 0.321; r = 0.294; P = .001, respectively). Gamma-glutamyl transferase was an independent predictor of left ventricular end-systolic volume and left ventricular end-diastolic volume, after adjustment for all variables. Gamma-glutamyl transferase correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.238, P = .009; r = 0.219, P = .016; r = 0.359, P < .001; r = 0.369, P = .001, respectively). CONCLUSIONS: Serum uric acid and gamma-glutamyl transferase levels are associated with left ventricular remodeling in patients with chronic ischemic heart failure.
Authors: Lina Miao; Ming Guo; Deng Pan; Pengfei Chen; Zhuhong Chen; Jie Gao; Yanqiao Yu; Dazhuo Shi; Jianpeng Du Journal: Front Med (Lausanne) Date: 2021-12-14