| Literature DB >> 25037082 |
Mazen M Dimachkie1, Richard J Barohn2.
Abstract
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecrotic muscle fibers often accompanied by rimmed vacuoles and protein deposits. It is likely that IBM is has a prominent degenerative component. This article reviews the evolution of knowledge in IBM, with emphasis on recent developments in the field, and discusses ongoing clinical trials.Entities:
Keywords: Diagnosis; Idiopathic inflammatory myopathies; Inclusion body myositis; Pathology; Pathophysiology; Polymyositis; Prognosis; Treatment
Mesh:
Year: 2014 PMID: 25037082 PMCID: PMC4115580 DOI: 10.1016/j.ncl.2014.04.001
Source DB: PubMed Journal: Neurol Clin ISSN: 0733-8619 Impact factor: 3.806