A Celal Iplikcioglu1, Mustafa Aziz Hatiboglu2, Erdinc Ozek3, Deniz Ozcan4. 1. Department of Neurosurgery, Harran University Medical School, Sanliurfa, Turkey. 2. Department of Neurosurgery, Bezmialem Vakif University Medical School, Istanbul, Turkey. Electronic address: azizhatiboglu@yahoo.com. 3. Department of Neurosurgery, Okmeydani Training and Research Hospital, Istanbul, Turkey. 4. Department of Pathology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Abstract
OBJECTIVE: Presence of steroid hormone receptors in meningiomas is well-known, but their correlation with tumour behaviour is unclear. The purpose of this study was to assess the relation between steroid hormone receptor expression and tumour behaviour. METHODS: We retrospectively reviewed 48 patients undergoing surgery for intracranial meningioma between January 2002 and December 2004. We included World Health Organization (WHO) Grade I meningiomas in Group 1 and WHO Grades II and III in Group 2. Tumour grade, progesterone receptor (PR), oestrogen receptor (ER) expressions, MIB-1 Index and Mitotic Index were assessed. We sought the correlation between tumour grade and MIB-1, Mitotic Indices, and also PR expression. Furthermore, the correlation between PR expression and MIB-1 and Mitotic Indices was assessed in Group 1 and Group 2, separately. RESULTS: 26 patients were in Group 1 and 22 patients in Group 2. PR expression was determined in 56% of the tumours while there was no ER expression. PR expression was found to be higher in Group 1 compared to Group 2. The Mean MIB-1 Index and the Mean Mitotic Index were significantly higher in Group 2 compared to Group 1. However, when Groups 1 and 2 were assessed separately, PR expression does not appear to be correlated with MIB-1 and Mitotic Indices in benign and also in non-benign meningioma groups. CONCLUSION: Our findings suggest that tumour grade, but not PR expression, is correlated with meningioma behaviour.
OBJECTIVE: Presence of steroid hormone receptors in meningiomas is well-known, but their correlation with tumour behaviour is unclear. The purpose of this study was to assess the relation between steroid hormone receptor expression and tumour behaviour. METHODS: We retrospectively reviewed 48 patients undergoing surgery for intracranial meningioma between January 2002 and December 2004. We included World Health Organization (WHO) Grade I meningiomas in Group 1 and WHO Grades II and III in Group 2. Tumour grade, progesterone receptor (PR), oestrogen receptor (ER) expressions, MIB-1 Index and Mitotic Index were assessed. We sought the correlation between tumour grade and MIB-1, Mitotic Indices, and also PR expression. Furthermore, the correlation between PR expression and MIB-1 and Mitotic Indices was assessed in Group 1 and Group 2, separately. RESULTS: 26 patients were in Group 1 and 22 patients in Group 2. PR expression was determined in 56% of the tumours while there was no ER expression. PR expression was found to be higher in Group 1 compared to Group 2. The Mean MIB-1 Index and the Mean Mitotic Index were significantly higher in Group 2 compared to Group 1. However, when Groups 1 and 2 were assessed separately, PR expression does not appear to be correlated with MIB-1 and Mitotic Indices in benign and also in non-benign meningioma groups. CONCLUSION: Our findings suggest that tumour grade, but not PR expression, is correlated with meningioma behaviour.
Authors: Sigrid Klotz; Christian Matula; Matthias Pones; Merima Herac; Anna Grisold; Johannes A Hainfellner; Gabor G Kovacs; Ellen Gelpi Journal: Clin Neuropathol Date: 2018 Nov/Dec Impact factor: 1.368
Authors: Francesco Maiuri; Giuseppe Mariniello; Oreste de Divitiis; Felice Esposito; Elia Guadagno; Giuseppe Teodonno; Marcello Barbato; Marialaura Del Basso De Caro Journal: Front Oncol Date: 2021-07-15 Impact factor: 6.244