Literature DB >> 25036835

Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate.

Ramya Mathiyalagan1, Sathiyamoorthy Subramaniyam, Yeon Ju Kim, Sathishkumar Natarajan, Jin Woo Min, Se Young Kim, Deok Chun Yang.   

Abstract

The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.

Entities:  

Keywords:  Panax ginseng; cancer; compound k; polyethylene glycol; solubility

Mesh：

Substances：

Year:  2014        PMID： 25036835     DOI： 10.1080/09168451.2014.885827

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  10 in total

Review 1.  Functional Mechanism of Ginsenoside Compound K on Tumor Growth and Metastasis.

Authors:  Jinlong Liu; Yuchen Wang; Zhun Yu; Guangfu Lv; Xiaowei Huang; He Lin; Chao Ma; Zhe Lin; Peng Qu
Journal:  Integr Cancer Ther       Date:  2022 Jan-Dec       Impact factor: 3.077

2.  Coalescence of functional gold and monodisperse silver nanoparticles mediated by black Panax ginseng Meyer root extract.

Authors:  Dandan Wang; Josua Markus; Yeon-Ju Kim; Chao Wang; Zuly Elizabeth Jiménez Pérez; Sungeun Ahn; Verónica Castro Aceituno; Ramya Mathiyalagan; Deok Chun Yang
Journal:  Int J Nanomedicine       Date:  2016-12-08

3.  Development of a single-nucleotide-polymorphism marker for specific authentication of Korean ginseng (Panax ginseng Meyer) new cultivar "G-1".

Authors:  Dong-Uk Yang; Min-Kyeoung Kim; Padmanaban Mohanan; Ramya Mathiyalagan; Kwang-Hoon Seo; Woo-Saeng Kwon; Deok-Chun Yang
Journal:  J Ginseng Res       Date:  2015-12-21       Impact factor: 6.060

4.  Targeted delivery of ginsenoside compound K using TPGS/PEG-PCL mixed micelles for effective treatment of lung cancer.

Authors:  Lei Yang; Zhenghai Zhang; Jian Hou; Xin Jin; Zhongcheng Ke; Dan Liu; Mei Du; Xiaobing Jia; Huixia Lv
Journal:  Int J Nanomedicine       Date:  2017-10-17

5.  Renshen Baidu powder protects ulcerative colitis via inhibiting the PI3K/Akt/NF-κB signaling pathway.

Authors:  Zhen Ye; Yuzheng Li; Yingqi She; Mingquan Wu; Yu Hu; Kaihua Qin; Linzhen Li; Han Yu; Qian Zhao; Zhao Jin; Fating Lu; Qiaobo Ye
Journal:  Front Pharmacol       Date:  2022-08-10       Impact factor: 5.988

6.  Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng.

Authors:  Ragavendran Abbai; Ramya Mathiyalagan; Josua Markus; Yeon-Ju Kim; Chao Wang; Priyanka Singh; Sungeun Ahn; Mohamed El-Agamy Farh; Deok Chun Yang
Journal:  Int J Nanomedicine       Date:  2016-07-11

7.  Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities.

Authors:  Chao Wang; Ramya Mathiyalagan; Yeon Ju Kim; Veronica Castro-Aceituno; Priyanka Singh; Sungeun Ahn; Dandan Wang; Deok Chun Yang
Journal:  Int J Nanomedicine       Date:  2016-08-10

8.  Preparation of ginsenoside compound-K mixed micelles with improved retention and antitumor efficacy.

Authors:  Xin Jin; Qing Yang; Ning Cai
Journal:  Int J Nanomedicine       Date:  2018-07-03

Review 9.  An Insight into Ginsenoside Metabolite Compound K as a Potential Tool for Skin Disorder.

Authors:  En Hyung Kim; Wonnam Kim
Journal:  Evid Based Complement Alternat Med       Date:  2018-06-25       Impact factor: 2.629

10.  Preparation of Polyethylene Glycol-Ginsenoside Rh1 and Rh2 Conjugates and Their Efficacy against Lung Cancer and Inflammation.

Authors:  Ramya Mathiyalagan; Chao Wang; Yeon Ju Kim; Verónica Castro-Aceituno; Sungeun Ahn; Sathiyamoorthy Subramaniyam; Shakina Yesmin Simu; Zuly Elizabeth Jiménez-Pérez; Deok Chun Yang; Seok-Kyu Jung
Journal:  Molecules       Date:  2019-11-29       Impact factor: 4.411
  10 in total

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