Literature DB >> 25036687

Determination by UPLC-MS of four dammarane-type saponins from heat-processed Gynostemma pentaphyllum.

Qian Wu1, Moonhee Jang, Xiang-Lan Piao.   

Abstract

Heat-processed Gynostemma pentaphyllum and its main dammaran-type saponins, gypenoside L, gypenoside LI, damulin B, and damulin A, possess non-small cell lung carcinoma A549 cell inhibitory activity. We established in this study a method by ultra-high performance liquid chromatography with tandem mass spectrometry for determination of the saponins and also investigated their content change in heat-processed G. pentaphyllum. The main saponins increased with increasing heating temperature and time. Further investigation showed that they were produced from gypenoside XLVI and gypenoside LVI by undergoing hydrolysis during the heat treatment.

Entities:  

Keywords:  Gynostemma pentaphyllum; damulin A; damulin B; gypenoside L; gypenoside LI

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Substances：

Year:  2014        PMID： 25036687     DOI： 10.1080/09168451.2014.882751

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  5 in total

1.  Effects of Plant Elicitors on Growth and Gypenosides Biosynthesis in Cell Culture of Giao co lam (Gynostemma pentaphyllum).

Authors:  Hoang Tan Quang; Pham Thi Diem Thi; Dang Ngoc Sang; Tran Thi Ngoc Tram; Nguyen Duc Huy; Tran Quoc Dung; Quach Thi Thu The
Journal:  Molecules       Date:  2022-05-06       Impact factor: 4.927

2.  Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.

Authors:  Chenghui Liao; Kai Zheng; Yan Li; Hong Xu; Qiangrong Kang; Long Fan; Xiaopeng Hu; Zhe Jin; Yong Zeng; Xiaoli Kong; Jian Zhang; Xuli Wu; Haiqiang Wu; Lizhong Liu; Xiaohua Xiao; Yifei Wang; Zhendan He
Journal:  Oncotarget       Date:  2016-07-26

3.  Comprehensive Profiling and Quantification of Ginsenosides in the Root, Stem, Leaf, and Berry of Panax ginseng by UPLC-QTOF/MS.

Authors:  Jae Won Lee; Bo-Ram Choi; Young-Chang Kim; Doo Jin Choi; Young-Seob Lee; Geum-Soog Kim; Nam-In Baek; Seung-Yu Kim; Dae Young Lee
Journal:  Molecules       Date:  2017-12-04       Impact factor: 4.411

4.  Gynostemma pentaphyllum for dyslipidemia: A systematic review of randomized controlled trials.

Authors:  Ning Dai; Fang-Fang Zhao; Min Fang; Feng-Lan Pu; Ling-Yao Kong; Jian-Ping Liu
Journal:  Front Pharmacol       Date:  2022-08-26       Impact factor: 5.988

5.  Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay.

Authors:  Ming Hong; Zhe Cai; Lei Song; Yongqiang Liu; Qi Wang; Xiangfei Feng
Journal:  Evid Based Complement Alternat Med       Date:  2018-03-21       Impact factor: 2.629
  5 in total

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