| Literature DB >> 25036630 |
Paul Andrew Muller1, Balázs Koscsó2, Gaurav Manohar Rajani2, Korey Stevanovic3, Marie-Luise Berres4, Daigo Hashimoto4, Arthur Mortha4, Marylene Leboeuf4, Xiu-Min Li5, Daniel Mucida6, E Richard Stanley7, Stephanie Dahan8, Kara Gross Margolis3, Michael David Gershon9, Miriam Merad10, Milena Bogunovic11.
Abstract
Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonstrate that, in the steady state, muscularis macrophages regulate peristaltic activity of the colon. They change the pattern of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons. Enteric neurons, in turn, secrete colony stimulatory factor 1 (CSF1), a growth factor required for macrophage development. Finally, stimuli from microbial commensals regulate BMP2 expression by macrophages and CSF1 expression by enteric neurons. Our findings identify a plastic, microbiota-driven crosstalk between muscularis macrophages and enteric neurons that controls gastrointestinal motility. PAPERFLICK:Entities:
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Year: 2014 PMID： 25036630 PMCID： PMC4149228 DOI： 10.1016/j.cell.2014.04.050
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582