Literature DB >> 25036627

γ-Secretase: a horseshoe structure brings good luck.

Michael S Wolfe1, Dennis J Selkoe2.   

Abstract

The intramembrane protease γ-secretase is a key player in signaling and Alzheimer's disease, but its structural features have remained obscure. A structure reported recently reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognition. This advance bodes well for a finer resolution before long.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25036627     DOI： 10.1016/j.cell.2014.06.043

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  6 in total

1.  Fused Morphlinopyrimidines and Methods of Use Thereof.

Authors:  Benjamin Blass
Journal:  ACS Med Chem Lett       Date:  2015-07-13       Impact factor: 4.345

2.  Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Authors:  David M Bolduc; Daniel R Montagna; Yongli Gu; Dennis J Selkoe; Michael S Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-22       Impact factor: 11.205

Review 3.  Membrane properties that shape the evolution of membrane enzymes.

Authors:  Charles R Sanders; James M Hutchison
Journal:  Curr Opin Struct Biol       Date:  2018-03-27       Impact factor: 6.809

4.  Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.

Authors:  Claudia Marinangeli; Bernadette Tasiaux; Rémi Opsomer; Salim Hage; Alejandro O Sodero; Ilse Dewachter; Jean Noël Octave; Steven O Smith; Stefan N Constantinescu; Pascal Kienlen-Campard
Journal:  J Biol Chem       Date:  2015-01-22       Impact factor: 5.157

Review 5.  The γ-secretase complex: from structure to function.

Authors:  Xian Zhang; Yanfang Li; Huaxi Xu; Yun-Wu Zhang
Journal:  Front Cell Neurosci       Date:  2014-12-11       Impact factor: 5.505

Review 6.  Organismal Protein Homeostasis Mechanisms.

Authors:  Thorsten Hoppe; Ehud Cohen
Journal:  Genetics       Date:  2020-08       Impact factor: 4.562
  6 in total

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