Literature DB >> 25035516

CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system.

Maria Cecilia G Marcondes1, Brenda Morsey2, Katy Emanuel2, Benjamin G Lamberty2, Claudia T Flynn1, Howard S Fox2.   

Abstract

Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  CD8; HIV; SIV; brain; cerebrospinal; immune

Mesh：

Substances：

Year:  2014        PMID： 25035516      PMCID： PMC4334822          DOI： 10.1093/infdis/jiu401

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

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