Literature DB >> 25035443

Confirmed viral meningitis with normal CSF findings.

Naghum Dawood1, Edouard Desjobert1, Janine Lumley1, Daniel Webster1, Michael Jacobs1.   

Abstract

An 18-year-old woman presented with a progressively worsening headache, photophobia feverishness and vomiting. Three weeks previously she had returned to the UK from a trip to Peru. At presentation, she had clinical signs of meningism. On admission, blood tests showed a mild lymphopenia, with a normal C reactive protein and white cell count. Chest X-ray and CT of the head were normal. Cerebrospinal fluid (CSF) microscopy was normal. CSF protein and glucose were in the normal range. MRI of the head and cerebral angiography were also normal. Subsequent molecular testing of CSF detected enterovirus RNA by reverse transcriptase PCR. The patient's clinical syndrome correlated with her virological diagnosis and no other cause of her symptoms was found. Her symptoms were self-limiting and improved with supportive management. This case illustrates an important example of viral central nervous system infection presenting clinically as meningitis but with normal CSF microscopy. 2014 BMJ Publishing Group Ltd.

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Year:  2014        PMID: 25035443      PMCID: PMC4112333          DOI: 10.1136/bcr-2014-203733

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  7 in total

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2.  Enterovirus reverse transcriptase polymerase chain reaction assay in cerebrospinal fluid: an essential tool in meningitis management in childhood.

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Journal:  Enferm Infecc Microbiol Clin       Date:  2012-12-11       Impact factor: 1.731

3.  Clinical presentation of patients with aseptic meningitis, factors influencing treatment and hospitalization, and consequences of enterovirus cerebrospinal fluid polymerase chain reaction testing.

Authors:  Glenn Patriquin; Jill Hatchette; Kevin Forward
Journal:  Can J Infect Dis Med Microbiol       Date:  2012       Impact factor: 2.471

4.  Clinical features of viral meningitis in adults: significant differences in cerebrospinal fluid findings among herpes simplex virus, varicella zoster virus, and enterovirus infections.

Authors:  Ugo K Ihekwaba; Goura Kudesia; Michael W McKendrick
Journal:  Clin Infect Dis       Date:  2008-09-15       Impact factor: 9.079

5.  Laboratory diagnosis of enteroviral infections of the central nervous system by using a nested RT-polymerase chain reaction (PCR) assay.

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Journal:  Diagn Microbiol Infect Dis       Date:  2003-12       Impact factor: 2.803

6.  Prospective comparison of culture vs genome detection for diagnosis of enteroviral meningitis in childhood.

Authors:  R E Tanel; S Y Kao; T M Niemiec; M J Loeffelholz; D T Holland; L A Shoaf; E R Stucky; J C Burns
Journal:  Arch Pediatr Adolesc Med       Date:  1996-09

7.  Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children.

Authors:  Katja C Wolthers; Kimberley S M Benschop; Janke Schinkel; Richard Molenkamp; Rosemarijn M Bergevoet; Ingrid J B Spijkerman; H Carlijn Kraakman; Dasja Pajkrt
Journal:  Clin Infect Dis       Date:  2008-08-01       Impact factor: 9.079

  7 in total
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  4 in total

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