Su Young Lee1, Aesun Shin2, Byung Chang Kim3, Jeong Hee Lee2, Kyung Su Han1, Chang Won Hong1, Dae Kyung Sohn1, Sung Chan Park1, Hee Jin Chang1, Jae Hwan Oh1. 1. Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea. 2. Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea. 3. Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea. Electronic address: mdzara@ncc.re.kr.
Abstract
PURPOSE: We assessed the association between a family history of malignancy and risk of colorectal adenoma among individuals aged 40-49 years. METHODS: The study population consisted of subjects, aged in their 40s, who underwent colonoscopy. Their family histories of cancer were collected with a self-administered questionnaire. A logistic regression model was used to assess the association between a family history of cancer and the risk of colorectal polyp. RESULTS: In total, 2275 participants were included in the study. Univariate analysis showed that old age, male sex, current cigarette smoking, BMI>25 kg/m(2), and a family history of colorectal cancer (CRC) were risk factors for the development of sporadic colorectal adenomatous polyps in these patients. A multivariate analysis showed that a family history of CRC or kidney cancer was associated with adenoma development. A family history of CRC was also a risk factor for advanced and multiple adenoma. CONCLUSIONS: This study shows that a family history of CRC is a risk factor for advanced and multiple colorectal adenoma in people in their 40s. These results support earlier screening for colorectal neoplasms in individuals with a family history of CRC.
PURPOSE: We assessed the association between a family history of malignancy and risk of colorectal adenoma among individuals aged 40-49 years. METHODS: The study population consisted of subjects, aged in their 40s, who underwent colonoscopy. Their family histories of cancer were collected with a self-administered questionnaire. A logistic regression model was used to assess the association between a family history of cancer and the risk of colorectal polyp. RESULTS: In total, 2275 participants were included in the study. Univariate analysis showed that old age, male sex, current cigarette smoking, BMI>25 kg/m(2), and a family history of colorectal cancer (CRC) were risk factors for the development of sporadic colorectal adenomatous polyps in these patients. A multivariate analysis showed that a family history of CRC or kidney cancer was associated with adenoma development. A family history of CRC was also a risk factor for advanced and multiple adenoma. CONCLUSIONS: This study shows that a family history of CRC is a risk factor for advanced and multiple colorectal adenoma in people in their 40s. These results support earlier screening for colorectal neoplasms in individuals with a family history of CRC.
Authors: Ji Yeon Kim; Yoon Suk Jung; Jung Ho Park; Hong Joo Kim; Yong Kyun Cho; Chong Il Sohn; Woo Kyu Jeon; Byung Ik Kim; Kyu Yong Choi; Dong Il Park Journal: World J Gastroenterol Date: 2016-04-07 Impact factor: 5.742
Authors: Shatha A Alduraywish; Leen A Altamimi; Ashwaq A Almajed; Bushra A Kokandi; Rawan S Alqahtani; Shatha G Alghaihb; Fahad M Aldakheel Journal: Prev Med Rep Date: 2020-10-26