Janice K Kiecolt-Glaser1, Diane L Habash2, Christopher P Fagundes3, Rebecca Andridge4, Juan Peng4, William B Malarkey5, Martha A Belury6. 1. Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio; Department of Psychiatry, College of Medicine, The Ohio State University, Columbus, Ohio. Electronic address: Janice.Kiecolt-Glaser@osumc.edu. 2. Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, Columbus, Ohio. 3. Department of Health Disparities Research, MD Anderson Cancer Center, Houston, Texas. 4. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio. 5. Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio; Department of Psychiatry, College of Medicine, The Ohio State University, Columbus, Ohio; Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio. 6. Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, Ohio.
Abstract
BACKGROUND:Depression and stress promote obesity. This study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals. METHODS: This double-blind, randomized, crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, cortisol, insulin, and glucose before and after two high-fat meals. During two separate 9.5-hour admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar control subjects), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. Prior day stressors were assessed by the Daily Inventory of Stressful Events. RESULTS: Greater numbers of stressors were associated with lower postmeal REE (p = .008), lower fat oxidation (p = .04), and higher insulin (p = .01), with nonsignificant effects for cortisol and glucose. Women with prior MDD had higher cortisol (p = .008) and higher fat oxidation (p = .004), without significant effects for REE, insulin, and glucose. Women with a depression history who also had more stressors had a higher peak triglyceride response than other participants (p = .01). The only difference between meals was higher postprandial glucose following sunflower oil compared with saturated fat (p = .03). CONCLUSIONS: The cumulative 6-hour difference between one prior day stressor and no stressors translates into 435 kJ, a difference that could add almost 11 pounds per year. These findings illustrate how stress and depression alter metabolic responses to high-fat meals in ways that promote obesity.
RCT Entities:
BACKGROUND:Depression and stress promote obesity. This study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals. METHODS: This double-blind, randomized, crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, cortisol, insulin, and glucose before and after two high-fat meals. During two separate 9.5-hour admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar control subjects), mean age 53.1 years, received either a high saturatedfat meal or a high oleicsunflower oil meal. Prior day stressors were assessed by the Daily Inventory of Stressful Events. RESULTS: Greater numbers of stressors were associated with lower postmeal REE (p = .008), lower fat oxidation (p = .04), and higher insulin (p = .01), with nonsignificant effects for cortisol and glucose. Women with prior MDD had higher cortisol (p = .008) and higher fat oxidation (p = .004), without significant effects for REE, insulin, and glucose. Women with a depression history who also had more stressors had a higher peak triglyceride response than other participants (p = .01). The only difference between meals was higher postprandial glucose following sunflower oil compared with saturatedfat (p = .03). CONCLUSIONS: The cumulative 6-hour difference between one prior day stressor and no stressors translates into 435 kJ, a difference that could add almost 11 pounds per year. These findings illustrate how stress and depression alter metabolic responses to high-fat meals in ways that promote obesity.
Authors: Nicole Vogelzangs; Stephen B Kritchevsky; Aartjan T F Beekman; Anne B Newman; Suzanne Satterfield; Eleanor M Simonsick; Kristine Yaffe; Tamara B Harris; Brenda W J H Penninx Journal: Arch Gen Psychiatry Date: 2008-12
Authors: Ellen E Blaak; Gabby Hul; Camilla Verdich; Vladimir Stich; Alfredo Martinez; Martin Petersen; Edith F M Feskens; Kishor Patel; Jean Michel Oppert; Pierre Barbe; Søren Toubro; Ingalena Anderson; Jan Polak; Arne Astrup; Ian A Macdonald; Dominique Langin; Claus Holst; Thorkild I Sørensen; Wim H M Saris Journal: J Clin Endocrinol Metab Date: 2006-01-31 Impact factor: 5.958
Authors: A Moles; A Bartolomucci; L Garbugino; R Conti; A Caprioli; R Coccurello; R Rizzi; B Ciani; F R D'Amato Journal: Psychoneuroendocrinology Date: 2006-04-17 Impact factor: 4.905
Authors: Toni I Pollin; Coleen M Damcott; Haiqing Shen; Sandra H Ott; John Shelton; Richard B Horenstein; Wendy Post; John C McLenithan; Lawrence F Bielak; Patricia A Peyser; Braxton D Mitchell; Michael Miller; Jeffrey R O'Connell; Alan R Shuldiner Journal: Science Date: 2008-12-12 Impact factor: 47.728
Authors: Patrick J Manning; Wayne H F Sutherland; Michelle M McGrath; Sylvia A de Jong; Robert J Walker; Michael J A Williams Journal: Obesity (Silver Spring) Date: 2008-09 Impact factor: 5.002
Authors: Diana A Chirinos; Luz M Garcini; Annina Seiler; Kyle W Murdock; Kristen Peek; Raymond P Stowe; Christopher Fagundes Journal: Ann Behav Med Date: 2019-08-16
Authors: Martha A Belury; Rachel M Cole; Brittney E Bailey; Jia-Yu Ke; Rebecca R Andridge; Janice K Kiecolt-Glaser Journal: Mol Nutr Food Res Date: 2016-03-22 Impact factor: 5.914
Authors: Janice K Kiecolt-Glaser; Stephanie J Wilson; Michael L Bailey; Rebecca Andridge; Juan Peng; Lisa M Jaremka; Christopher P Fagundes; William B Malarkey; Bryon Laskowski; Martha A Belury Journal: Psychoneuroendocrinology Date: 2018-08-04 Impact factor: 4.905
Authors: Luz M Garcini; Diana A Chirinos; Kyle W Murdock; Annina Seiler; Angie S LeRoy; Kristen Peek; Malcom P Cutchin; Christopher Fagundes Journal: J Behav Med Date: 2017-12-21