Hepatitis B immunisation in northern Ireland: an epidemiological and economic analysis.

The availability of active immunisation against hepatitis B has stimulated demand for protection among health care workers. The vaccine remains expensive, and widespread immunisation will divert scarce resources from elsewhere. The arguments in favour of widespread immunisation of health care workers are based on studies from areas with prevalences of infection and carriage which are much higher than in Northern Ireland. This study was carried out to provide a rational basis for deciding who should be offered immunisation. The epidemiology of hepatitis B infection in Northern Ireland is examined. The incidence of hepatitis B in Northern Ireland is one of the lowest in the world. The evidence for an increased risk of infection among health care workers throughout the world is reviewed. The risk of infection varies widely among different countries and there is evidence that increased awareness of the hazards of sharps injuries and the introduction of safe handling techniques have substantially reduced the risk. An economic analysis suggests that a widespread programme of hepatitis B immunisation in Northern Ireland compares unfavourably with other health care interventions.