| Literature DB >> 25034614 |
Mohammed M Ghoneim1, Khaled M Elokely2, Atef A El-Hela3, Abd-Elsalam I Mohammad3, Melissa Jacob4, Mohamed M Radwan5, Robert J Doerksen6, Stephen J Cutler6, Samir A Ross7.
Abstract
Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm. et Viv. (Xanthorrhoeaceae or Asphodelaceae) resulted in isolation of five compounds identified as asphodosides A-E (1-5). Compounds 2-4 showed activity against methicillin resistant Staphylococcus aureus (MRSA) with IC50 values of 1.62, 7.0 and 9.0μg/mL, respectively. They also exhibited activity against Staphylococcus aureus (non-MRSA) with IC50 values of 1.0, 3.4 and 2.2μg/mL, respectively. The structure elucidation of isolated metabolites was carried out using spectroscopic data (1D and 2D NMR), optical rotation and both experimental and calculated electronic circular dichroism (ECD).Entities:
Keywords: Asphodelaceae; Asphodelus microcarpus; Electronic circular dichroism; MRSA
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Year: 2014 PMID： 25034614 PMCID： PMC4883109 DOI： 10.1016/j.phytochem.2014.06.011
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072