Literature DB >> 25034413

Epstein-Barr virus (EBV)-encoded dUTPase and chronic restraint induce impaired learning and memory and sickness responses.

Taryn G Aubrecht1, Zachary M Weil1, Maria Eugenia Ariza2, Marshall Williams2, Brenda F Reader3, Ronald Glaser4, John F Sheridan5, Randy J Nelson1.   

Abstract

Most adult humans have been infected with Epstein-Barr virus (EBV) and carry the latent virus. The EBV genome codes for several proteins that form an early antigen complex important for viral replication; one of these proteins is deoxyuridine triphosphate nucleotidohydrolase (dUTPase). The EBV-encoded dUTPase can induce sickness responses in mice. Because stress can increase latent virus reactivation, we hypothesized that chronic restraint would exacerbate sickness behaviors elicited by EBV-encoded dUTPase. Male Swiss-Webster mice were injected daily for 15 days with either saline or EBV-encoded dUTPase. Additionally, half of the mice from each condition were either restrained for 3h daily or left undisturbed. Restraint stress impaired learning and memory in the passive avoidance chamber; impaired learning and memory was due to EBV-encoded dUTPase injected into restrained mice. EBV-encoded dUTPase induced sickness responses and restraint stress interacts with EBV-encoded dUTPase to exacerbate the sickness response. These data support a role for EBV-encoded dUTPase and restraint stress in altering the pathophysiology of EBV independent of viral replication.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Chronic restraint stress; Epstein–Barr virus; Learning and memory; Sickness response

Mesh：

Substances：

Year:  2014        PMID： 25034413      PMCID： PMC4184975          DOI： 10.1016/j.physbeh.2014.07.001

Source DB:  PubMed          Journal:  Physiol Behav        ISSN： 0031-9384


  32 in total

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3.  Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

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