Literature DB >> 25034240

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle.

Zhonggao Wang1, Zhiwei Hu, Jimin Wu, Feng Ji, Hongtao Wang, Yungang Lai, Xiang Gao, Yachan Ning, Chengchao Zhang, Zhitong Li, Weitao Liang, Jianjun Liu.   

Abstract

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team's work and would call attention to the public so as to recognize this relatively unknown entity - a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

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Year:  2014        PMID: 25034240     DOI: 10.1007/s11684-014-0343-1

Source DB:  PubMed          Journal:  Front Med        ISSN: 2095-0217            Impact factor:   4.592


  27 in total

1.  Is GERD-induced asthma a different disease entity?

Authors:  Zhonggao Wang; Raj M Kotwal
Journal:  Ther Adv Respir Dis       Date:  2011-10-19       Impact factor: 4.031

2.  Modulation of upper and lower esophageal sphincter tone during sleep.

Authors:  Peter R Eastwood; Sawako Katagiri; Kelly L Shepherd; David R Hillman
Journal:  Sleep Med       Date:  2007-02-01       Impact factor: 3.492

3.  Respiratory distress resulting from gastroesophageal reflux is not asthma, but laryngotracheal irritation, spasm, even suffocation.

Authors:  Zhong-gao Wang; Ji-min Wu; Jian-jun Liu; Li-yin Wang; Yun-gang Lai; Ibrahim M Ibrahim; Xiu-jie Wang; Herbert Dardik
Journal:  Chin Med Sci J       Date:  2009-06

Review 4.  The effects of antireflux surgery on asthmatics with gastroesophageal reflux.

Authors:  S K Field; G A Gelfand; S D McFadden
Journal:  Chest       Date:  1999-09       Impact factor: 9.410

5.  Experimental study for the mechanism of gastroesophageal-reflux-associated asthma.

Authors:  G-C Zhu; Xiang Gao; Z-G Wang; Z-W Hu; C-C Zhang; Y-G Lai; F Ji; J-M Wu
Journal:  Dis Esophagus       Date:  2013-09-05       Impact factor: 3.429

6.  Relationship between dental erosion and respiratory symptoms in patients with gastro-oesophageal reflux disease.

Authors:  Geng-Ru Wang; Hui Zhang; Zhong-Gao Wang; Guang-Shui Jiang; Cheng-Hao Guo
Journal:  J Dent       Date:  2010-08-07       Impact factor: 4.379

7.  Animal study for airway inflammation triggered by gastroesophageal reflux.

Authors:  Yun-gang Lai; Zhong-gao Wang; Feng Ji; Ji-min Wu; Xiu Chen; Zhen Li; Shu-kui Dong
Journal:  Chin Med J (Engl)       Date:  2009-11-20       Impact factor: 2.628

8.  Globus sensation and increased upper esophageal sphincter pressure with distal esophageal acid perfusion.

Authors:  Ryoji Tokashiki; Nobutoshi Funato; Mamoru Suzuki
Journal:  Eur Arch Otorhinolaryngol       Date:  2009-11-01       Impact factor: 2.503

9.  Laparoscopic Nissen fundoplication is more effective intreating patients with GERD-related chronic cough than Stretta radiofrequency.

Authors:  W Liang; J Wu; Z Hu; Z Wang; G Zhu; C Zhang
Journal:  Minerva Chir       Date:  2014-05-14       Impact factor: 1.000

10.  Anti-reflux procedure for difficult-to-treat asthmatic children, case report and literature review.

Authors:  Zhi-Wei Hu; Zhong-Gao Wang; Ji-Min Wu; Song-Tao Tan
Journal:  Multidiscip Respir Med       Date:  2012-09-14
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  3 in total

1.  Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease.

Authors:  Zhiwei Hu; Meiping Chen; Jimin Wu; Qing Song; Chao Yan; Xing Du; Zhonggao Wang
Journal:  Front Med       Date:  2017-03-02       Impact factor: 4.592

2.  Diagnosis and Anti-Reflux Therapy for GERD with Respiratory Symptoms: A Study Using Multichannel Intraluminal Impedance-pH Monitoring.

Authors:  Chao Zhang; Jimin Wu; Zhiwei Hu; Chao Yan; Xiang Gao; Weitao Liang; Diangang Liu; Fei Li; Zhonggao Wang
Journal:  PLoS One       Date:  2016-08-17       Impact factor: 3.240

3.  Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale.

Authors:  Chao Zhang; Zhi-Wei Hu; Chao Yan; Qiong Wu; Ji-Min Wu; Xing Du; Dian-Gang Liu; Tao Luo; Fei Li; Zhong-Gao Wang
Journal:  World J Gastroenterol       Date:  2017-05-21       Impact factor: 5.742

  3 in total

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