Violaine Tolsma1, Carole Schwebel1, Elie Azoulay2, Michael Darmon3, Bertrand Souweine4, Aurélien Vesin1, Dany Goldgran-Toledano5, Maxime Lugosi1, Samir Jamali6, Christine Cheval7, Christophe Adrie8, Hatem Kallel9, Adrien Descorps-Declere10, Maïté Garrouste-Orgeas11, Lila Bouadma12, Jean-François Timsit13. 1. From the A. Michallon University Hospital, INSERM U823 and Joseph Fourier University, Grenoble. 2. Saint-Louis University Hospital, Paris. 3. Saint-Etienne University Hospital, Saint-Etienne. 4. Gabriel Montpied University Hospital, Clermont-Ferrand. 5. Gonesse Hospital Gonesse. 6. Dourdan Hospital Dourdan. 7. Hyeres Hospital Hyeres. 8. Delafontaine Hospital, Saint-Denis. 9. Cayenne Hospital French Guyana. 10. A. Beclere Hospital, Clamart. 11. Saint-Joseph Hospital Network, Paris; IAME UMR 1137, University Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France. 12. AP-HP, Bichat Hospital Medical and Infectious Diseases ICU, F-75018, Paris; IAME UMR 1137, University Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France. 13. From the A. Michallon University Hospital, INSERM U823 and Joseph Fourier University, Grenoble; AP-HP, Bichat Hospital Medical and Infectious Diseases ICU, F-75018, Paris; IAME UMR 1137, University Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France. Electronic address: Jean-francois.timsit@bch.aphp.fr.
Abstract
OBJECTIVES: This study evaluated the influence of the immune profile on the outcome at day 28 (D28) of patients admitted to the ICU for septic shock or severe sepsis. METHODS: We conducted an observational study using a prospective multicenter database and included all patients admitted to 11 ICUs for severe sepsis or septic shock from January 1997 to August 2011. Seven profiles of immunodeficiency were defined. The prognostic analysis used a competitive risk model (Fine and Gray), in which being alive at ICU or hospital discharge before D28 competed with death. RESULTS: Among the 1,981 included patients, 607 (31%) were immunocompromised (including nonneutropenic solid tumor [19.6%], nonneutropenic hematologic malignancies [26.3%], and all-cause neutropenia [28%]). Compared with immunocompetent patients, immunocompromised patients were younger, with less comorbidity, were more often admitted for medical reasons, and presented less often with septic shock. The D28 crude mortality was 31.3% in immunocompromised patients and 28.8% in immunocompetent patients (P = .26). However, after adjustment for other prognostic factors, immunodeficiency was an independent risk factor for death at D28 (subdistribution hazard ratio [sHR], 1.37; 95% CI, 1.12-1.67). The immunodeficiency profiles independently associated with death were AIDS (sHR = 1.9), non-neutropenic solid tumor (sHR = 1.8), nonneutropenic hematologic malignancies (sHR = 1.4), and all-cause neutropenia (sHR = 1.7). CONCLUSIONS: Immunodeficiency is common in patients with severe sepsis or septic shock. Despite a similar crude mortality, immunodeficiency was associated with an increased risk of short-term mortality after multivariate analysis. Neutropenia and specific, but not all, profiles of immunodeficiency were independently associated with an increased risk of death.
OBJECTIVES: This study evaluated the influence of the immune profile on the outcome at day 28 (D28) of patients admitted to the ICU for septic shock or severe sepsis. METHODS: We conducted an observational study using a prospective multicenter database and included all patients admitted to 11 ICUs for severe sepsis or septic shock from January 1997 to August 2011. Seven profiles of immunodeficiency were defined. The prognostic analysis used a competitive risk model (Fine and Gray), in which being alive at ICU or hospital discharge before D28 competed with death. RESULTS: Among the 1,981 included patients, 607 (31%) were immunocompromised (including nonneutropenic solid tumor [19.6%], nonneutropenic hematologic malignancies [26.3%], and all-cause neutropenia [28%]). Compared with immunocompetent patients, immunocompromised patients were younger, with less comorbidity, were more often admitted for medical reasons, and presented less often with septic shock. The D28 crude mortality was 31.3% in immunocompromised patients and 28.8% in immunocompetent patients (P = .26). However, after adjustment for other prognostic factors, immunodeficiency was an independent risk factor for death at D28 (subdistribution hazard ratio [sHR], 1.37; 95% CI, 1.12-1.67). The immunodeficiency profiles independently associated with death were AIDS (sHR = 1.9), non-neutropenic solid tumor (sHR = 1.8), nonneutropenic hematologic malignancies (sHR = 1.4), and all-cause neutropenia (sHR = 1.7). CONCLUSIONS:Immunodeficiency is common in patients with severe sepsis or septic shock. Despite a similar crude mortality, immunodeficiency was associated with an increased risk of short-term mortality after multivariate analysis. Neutropenia and specific, but not all, profiles of immunodeficiency were independently associated with an increased risk of death.
Authors: Kevin Mo; Arjun Gupta; Humaid Al Farii; Micheal Raad; Farah Musharbash; Britni Tran; Ming Zheng; Sang Hun Lee Journal: J Spine Surg Date: 2022-06
Authors: Julie Ng; Fei Guo; Anna E Marneth; Sailaja Ghanta; Min-Young Kwon; Joshua Keegan; Xiaoli Liu; Kyle T Wright; Baransel Kamaz; Laura A Cahill; Ann Mullally; Mark A Perrella; James A Lederer Journal: Blood Adv Date: 2020-10-13