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Literature DB >> 25033025

Circadian clock: linking epigenetics to aging.

Ricardo Orozco-Solis¹, Paolo Sassone-Corsi².

Abstract

Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features. Importantly, environmental conditions are thought to modulate the aging process. For example, caloric restriction is a very strong environmental effector capable of delaying aging. Intracellular pathways implicating nutrient sensors, such as SIRTs and mTOR complexes, impinge on cellular and epigenetic mechanisms that control the aging process. Strikingly, accumulating evidences indicate that these pathways are involved in both the modulation of the aging process and the control of the clock. Hence, innovative therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25033025 PMCID： PMC5472345 DOI： 10.1016/j.gde.2014.06.003

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

55 in total

Review 1. Hypothalamic regulation of sleep and circadian rhythms.

Authors: Clifford B Saper; Thomas E Scammell; Jun Lu
Journal: Nature Date: 2005-10-27 Impact factor: 49.962

2. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.

Authors: Megumi Hatori; Christopher Vollmers; Amir Zarrinpar; Luciano DiTacchio; Eric A Bushong; Shubhroz Gill; Mathias Leblanc; Amandine Chaix; Matthew Joens; James A J Fitzpatrick; Mark H Ellisman; Satchidananda Panda
Journal: Cell Metab Date: 2012-05-17 Impact factor: 27.287

Review 3. Living by the clock: the circadian pacemaker in older people.

Authors: Michel A Hofman; Dick F Swaab
Journal: Ageing Res Rev Date: 2005-08-25 Impact factor: 10.895

4. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption.

Authors: Orfeu M Buxton; Sean W Cain; Shawn P O'Connor; James H Porter; Jeanne F Duffy; Wei Wang; Charles A Czeisler; Steven A Shea
Journal: Sci Transl Med Date: 2012-04-11 Impact factor: 17.956

5. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

Authors: Yasukazu Nakahata; Milota Kaluzova; Benedetto Grimaldi; Saurabh Sahar; Jun Hirayama; Danica Chen; Leonard P Guarente; Paolo Sassone-Corsi
Journal: Cell Date: 2008-07-25 Impact factor: 41.582

6. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.

Authors: Carla S Möller-Levet; Simon N Archer; Giselda Bucca; Emma E Laing; Ana Slak; Renata Kabiljo; June C Y Lo; Nayantara Santhi; Malcolm von Schantz; Colin P Smith; Derk-Jan Dijk
Journal: Proc Natl Acad Sci U S A Date: 2013-02-25 Impact factor: 11.205

7. SIRT3 reverses aging-associated degeneration.

Authors: Katharine Brown; Stephanie Xie; Xiaolei Qiu; Mary Mohrin; Jiyung Shin; Yufei Liu; Dan Zhang; David T Scadden; Danica Chen
Journal: Cell Rep Date: 2013-01-31 Impact factor: 9.423

8. Circadian acetylome reveals regulation of mitochondrial metabolic pathways.

Authors: Selma Masri; Vishal R Patel; Kristin L Eckel-Mahan; Shahaf Peleg; Ignasi Forne; Andreas G Ladurner; Pierre Baldi; Axel Imhof; Paolo Sassone-Corsi
Journal: Proc Natl Acad Sci U S A Date: 2013-01-22 Impact factor: 11.205

Review 9. Regulation of circadian clocks by redox homeostasis.

Authors: Alessandra Stangherlin; Akhilesh B Reddy
Journal: J Biol Chem Date: 2013-07-16 Impact factor: 5.157

10. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

Authors: Kathryn Moynihan Ramsey; Jun Yoshino; Cynthia S Brace; Dana Abrassart; Yumiko Kobayashi; Biliana Marcheva; Hee-Kyung Hong; Jason L Chong; Ethan D Buhr; Choogon Lee; Joseph S Takahashi; Shin-Ichiro Imai; Joseph Bass
Journal: Science Date: 2009-03-19 Impact factor: 47.728

29 in total

Review 1. Histone Deacetylases in Bone Development and Skeletal Disorders.

Authors: Elizabeth W Bradley; Lomeli R Carpio; Andre J van Wijnen; Meghan E McGee-Lawrence; Jennifer J Westendorf
Journal: Physiol Rev Date: 2015-10 Impact factor: 37.312

Review 2. Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Authors: Bérénice A Benayoun; Elizabeth A Pollina; Anne Brunet
Journal: Nat Rev Mol Cell Biol Date: 2015-09-16 Impact factor: 94.444

Review 3. Successful aging: Advancing the science of physical independence in older adults.

Authors: Stephen D Anton; Adam J Woods; Tetso Ashizawa; Diana Barb; Thomas W Buford; Christy S Carter; David J Clark; Ronald A Cohen; Duane B Corbett; Yenisel Cruz-Almeida; Vonetta Dotson; Natalie Ebner; Philip A Efron; Roger B Fillingim; Thomas C Foster; David M Gundermann; Anna-Maria Joseph; Christy Karabetian; Christiaan Leeuwenburgh; Todd M Manini; Michael Marsiske; Robert T Mankowski; Heather L Mutchie; Michael G Perri; Sanjay Ranka; Parisa Rashidi; Bhanuprasad Sandesara; Philip J Scarpace; Kimberly T Sibille; Laurence M Solberg; Shinichi Someya; Connie Uphold; Stephanie Wohlgemuth; Samuel Shangwu Wu; Marco Pahor
Journal: Ageing Res Rev Date: 2015-10-14 Impact factor: 10.895

Circadian clock: linking epigenetics to aging.

Review 1. Hypothalamic regulation of sleep and circadian rhythms.

2. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.

Review 3. Living by the clock: the circadian pacemaker in older people.

4. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption.

5. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

6. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.

7. SIRT3 reverses aging-associated degeneration.

8. Circadian acetylome reveals regulation of mitochondrial metabolic pathways.

Review 9. Regulation of circadian clocks by redox homeostasis.

10. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

Review 1. Histone Deacetylases in Bone Development and Skeletal Disorders.

Review 2. Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Review 3. Successful aging: Advancing the science of physical independence in older adults.

4. When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

5. Aging and chromatoid body assembly: Are these two physiological events linked?

Review 6. Mitochondrial maintenance failure in aging and role of sexual dimorphism.

7. Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription.

Review 8. How does healthy aging impact on the circadian clock?

9. The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure.

10. Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.