Literature DB >> 2503226

Effect of chronic intra-accumbens administration of the TRH analogue CG3509 on histamine-induced behaviour in the rat.

L J Bristow1, G W Bennett.   

Abstract

1. The present study has investigated the effect of chronic intra-accumbens administration of the thyrotrophin-releasing hormone (TRH) analogue, CG3509, on CG3509- and histamine-induced spontaneous motor activity and brain TRH-like immunoreactive (TRH-LI) levels in the rat. 2. Chronic intra-accumbens administration of CG3509 (5 x 5 micrograms over 3 days) induced: (a) a significant (P less than 0.05) reduction in intra-accumbens CG3509 (0.5 micrograms)-induced hyperactivity, (b) reduced levels of TRH-LI in the nucleus accumbens but not other brain regions, (c) a marked increase (107%, P less than 0.01) in histamine-induced non-locomotor hyperactivity. 3. The present results demonstrate that alteration of central TRH function following treatment with a TRH analogue enhances the effect of intra-accumbens histamine on behavioural hyperactivity, possibly via changes in H1 receptors and suggest that the neuropeptide, TRH and histamine interact in behavioural arousal mechanisms in rat brain.

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Year:  1989        PMID： 2503226      PMCID： PMC1854565          DOI： 10.1111/j.1476-5381.1989.tb12012.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  27 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors.

Authors:  J M Arrang; M Garbarg; J C Schwartz
Journal:  Neuroscience       Date:  1987-10       Impact factor: 3.590

3.  Biphasic effects of intra-accumbens histamine administration on spontaneous motor activity in the rat; a role for central histamine receptors.

Authors:  L J Bristow; G W Bennett
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

Review 4.  Histamine as a neuroregulator.

Authors:  G D Prell; J P Green
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5.  The preparation and specificity of antibody to thyrotropin releasing hormone.

Authors:  R M Bassiri; R D Utiger
Journal:  Endocrinology       Date:  1972-03       Impact factor: 4.736

6.  Treatment of rats with the TRH analog MK-771. Down-regulation of TRH receptors and behavioral tolerance.

Authors:  S M Simasko; A Horita
Journal:  Neuropharmacology       Date:  1985-02       Impact factor: 5.250

7.  Involvement of catecholaminergic neurones and alpha-adrenoceptors in the wet-dog shake and forepaw licking behaviour produced by the intrathecal injection of an analogue of thyrotrophin-releasing hormone (CG 3509).

Authors:  K C Fone; G W Bennett; C A Marsden
Journal:  Neuropharmacology       Date:  1987-08       Impact factor: 5.250

8.  Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues.

Authors:  D J Heal; N Stoodley; J M Elliott; C A Marsden; G W Bennett; M B Youdim
Journal:  Neuropharmacology       Date:  1987-04       Impact factor: 5.250

9.  Mesolimbic involvement in the locomotor stimulant action of thyrotropin-releasing hormone (TRH) in rats.

Authors:  M Miyamoto; Y Nagawa
Journal:  Eur J Pharmacol       Date:  1977-07-15       Impact factor: 4.432

10.  Spinal effects of chronic intrathecal administration of the thyrotrophin-releasing hormone analogue (CG 3509) in rats.

Authors:  K C Fone; P Dix; D R Tomlinson; G W Bennett; C A Marsden
Journal:  Brain Res       Date:  1988-07-05       Impact factor: 3.252
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  2 in total

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

2.  Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei.

Authors:  Edith Sánchez-Jaramillo; Gábor Wittmann; Judit Menyhért; Praful Singru; Gabriela B Gómez-González; Eduardo Sánchez-Islas; Nashiely Yáñez-Recendis; Jaime Arturo Pimentel-Cabrera; Martha León-Olea; Balázs Gereben; Csaba Fekete; Jean-Louis Charli; Ronald M Lechan
Journal:  Brain Struct Funct       Date:  2022-08-07       Impact factor: 3.748
  2 in total

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