AIM: To determine if a new brush design could improve the diagnostic yield of biliary stricture brushings. METHODS: Retrospective chart review was performed of all endoscopic retrograde cholangiopancreatography procedures with malignant biliary stricture brushing between January 2008 and October 2012. A standard wire-guided cytology brush was used prior to protocol implementation in July 2011, after which, a new 9 French wire-guided cytology brush (Infinity sampling device, US Endoscopy, Mentor, OH) was used for all cases. All specimens were reviewed by blinded pathologists who determined whether the sample was positive or negative for malignancy. Cellular yield was quantified by describing the number of cell clusters seen. RESULTS: Thirty-two new brush cases were compared to 46 historical controls. Twenty-five of 32 (78%) cases in the new brush group showed abnormal cellular findings consistent with malignancy as compared to 17 of 46 (37%) in the historical control group (P = 0.0003). There was also a significant increase in the average number of cell clusters of all sizes (21.1 vs 9.9 clusters, P = 0.0007) in the new brush group compared to historical controls. CONCLUSION: The use of a new brush design for brush cytology of biliary strictures shows increased diagnostic accuracy, likely due to improved cellular yield, as evidenced by an increase in number of cellular clusters obtained.
AIM: To determine if a new brush design could improve the diagnostic yield of biliary stricture brushings. METHODS: Retrospective chart review was performed of all endoscopic retrograde cholangiopancreatography procedures with malignant biliary stricture brushing between January 2008 and October 2012. A standard wire-guided cytology brush was used prior to protocol implementation in July 2011, after which, a new 9 French wire-guided cytology brush (Infinity sampling device, US Endoscopy, Mentor, OH) was used for all cases. All specimens were reviewed by blinded pathologists who determined whether the sample was positive or negative for malignancy. Cellular yield was quantified by describing the number of cell clusters seen. RESULTS: Thirty-two new brush cases were compared to 46 historical controls. Twenty-five of 32 (78%) cases in the new brush group showed abnormal cellular findings consistent with malignancy as compared to 17 of 46 (37%) in the historical control group (P = 0.0003). There was also a significant increase in the average number of cell clusters of all sizes (21.1 vs 9.9 clusters, P = 0.0007) in the new brush group compared to historical controls. CONCLUSION: The use of a new brush design for brush cytology of biliary strictures shows increased diagnostic accuracy, likely due to improved cellular yield, as evidenced by an increase in number of cellular clusters obtained.
Authors: M Rabinovitz; A B Zajko; T Hassanein; B Shetty; K M Bron; R R Schade; J S Gavaler; G Block; D H Van Thiel; A Dekker Journal: Hepatology Date: 1990-10 Impact factor: 17.425
Authors: Emily G Barr Fritcher; Benjamin R Kipp; Kevin C Halling; Trynda N Oberg; Sandra C Bryant; Robert F Tarrell; Gregory J Gores; Michael J Levy; Amy C Clayton; Thomas J Sebo; Lewis R Roberts Journal: Gastroenterology Date: 2009-02-14 Impact factor: 22.682
Authors: Thomas Rösch; Kim Hofrichter; Eckart Frimberger; Alexander Meining; Peter Born; Norbert Weigert; Hans-Dieter Allescher; Meinhard Classen; Marius Barbur; Ulrich Schenck; Martin Werner Journal: Gastrointest Endosc Date: 2004-09 Impact factor: 9.427
Authors: Muhammad Nadeem Yousaf; Hamid Ehsan; Ahsan Wahab; Ahmad Muneeb; Fizah S Chaudhary; Richard Williams; Christopher J Haas Journal: World J Gastrointest Endosc Date: 2020-10-16
Authors: Daniel Pörner; Dominik J Kaczmarek; Dominik Heling; Annekristin Hausen; Raphael Mohr; Robert Hüneburg; Hanno Matthaei; Tim R Glowka; Steffen Manekeller; Hans-Peter Fischer; Marieta Toma; Jacob Nattermann; Christian P Strassburg; Maria A Gonzalez-Carmona; Tobias J Weismüller Journal: Sci Rep Date: 2020-10-15 Impact factor: 4.379
Authors: Abdulsemed M Nur; Misbah Salim; Scott Boerner; Suqing Li; Cindy C Y Law; Leanne Edwards; Kaitlin Ryan; Paul D James Journal: J Can Assoc Gastroenterol Date: 2022-05-05
Authors: Gael S Roth; Philippe Bichard; Michele Fior-Gozlan; Hubert Roth; Jean Auroux; Olivier Risse; Christian Letoublon; Marie Hélène Laverrière; Ivan Bricault; Vincent Leroy; Thomas Decaens Journal: Endosc Int Open Date: 2016-08-09