Literature DB >> 25031725

LncRNA TSLC1-AS1 is a novel tumor suppressor in glioma.

Xiaoyong Qin1, Jie Yao2, Peiliang Geng3, Xiangping Fu4, Jinghui Xue4, Zhiwen Zhang4.   

Abstract

Growing evidence demonstrates that long non coding RNAs (lncRNAs) play an important role in cancer origination and progression. A novel lncRNA, TSLC1-AS1, is the antisense transcript of tumor suppressor TSLC1. The expression profile and function of TSLC1-AS1 in glioma were investigated using Real-Time Quantitative PCR and siRNA knockdown. The data showed that TSLC1-AS1 expression was down-regulated in tumor tissues compared with that in adjacent normal tissues, and negatively associated with the WHO criteria of the tumors. Overexpression of TSLC1-AS1 resulted in up-regulation of TSLC1 and significant inhibition of cell proliferation, migration and invasion in U87 cells, while knockdown of TSLC1-AS1 in SNB-19 cells showed the opposite effect. The expression of TSLC1-AS1 was also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF. The results suggested that TSLC1-AS1 was a tumor suppressor of glioma and a mediator of TSLC1 expression. LncRNA TSLC1-AS1 may serve as a potential biomarker and therapeutic target for glioma.

Entities:  

Keywords:  Long non coding RNAs; glioma; tumor suppressor

Mesh：

Substances：

Year:  2014        PMID： 25031725      PMCID： PMC4097230     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  30 in total

1.  TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.

Authors:  M Kuramochi; H Fukuhara; T Nobukuni; T Kanbe; T Maruyama; H P Ghosh; M Pletcher; M Isomura; M Onizuka; T Kitamura; T Sekiya; R H Reeves; Y Murakami
Journal:  Nat Genet       Date:  2001-04       Impact factor: 38.330

Review 2.  Long non-coding RNAs and cancer: a new frontier of translational research?

Authors:  R Spizzo; M I Almeida; A Colombatti; G A Calin
Journal:  Oncogene       Date:  2012-01-23       Impact factor: 9.867

3.  Widespread occurrence of antisense transcription in the human genome.

Authors:  Rodrigo Yelin; Dvir Dahary; Rotem Sorek; Erez Y Levanon; Orly Goldstein; Avi Shoshan; Alex Diber; Sharon Biton; Yael Tamir; Rami Khosravi; Sergey Nemzer; Elhanan Pinner; Shira Walach; Jeanne Bernstein; Kinneret Savitsky; Galit Rotman
Journal:  Nat Biotechnol       Date:  2003-03-17       Impact factor: 54.908

4.  Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.

Authors:  Biplab Dasgupta; Wen Li; Arie Perry; David H Gutmann
Journal:  Cancer Res       Date:  2005-01-01       Impact factor: 12.701

5.  Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs.

Authors:  Marnix Jansen; Noriyoshi Fukushima; Christophe Rosty; Kim Walter; Renee Altink; Tjarda Van Heek; Ralph Hruban; Johan G Offerhaus; Michael Goggins
Journal:  Cancer Biol Ther       Date:  2002 May-Jun       Impact factor: 4.742

Review 6.  Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis.

Authors:  Yoshinori Murakami
Journal:  Cancer Sci       Date:  2005-09       Impact factor: 6.716

Review 7.  IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function.

Authors:  K Watabe; A Ito; Y-I Koma; Y Kitamura
Journal:  Histol Histopathol       Date:  2003-10       Impact factor: 2.303

8.  Involvement of TSLC1 in progression of esophageal squamous cell carcinoma.

Authors:  Tetsuo Ito; Yutaka Shimada; Yosuke Hashimoto; Junichi Kaganoi; Takatsugu Kan; Go Watanabe; Yoshinori Murakami; Masayuki Imamura
Journal:  Cancer Res       Date:  2003-10-01       Impact factor: 12.701

9.  aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia.

Authors:  C A Thrash-Bingham; K D Tartof
Journal:  J Natl Cancer Inst       Date:  1999-01-20       Impact factor: 13.506

10.  Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines.

Authors:  Teiichiro Honda; Gen Tamura; Takayoshi Waki; Zhe Jin; Kiyoshi Sato; Teiichi Motoyama; Sumio Kawata; Wataru Kimura; Satoshi Nishizuka; Yoshinori Murakami
Journal:  Jpn J Cancer Res       Date:  2002-08
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  26 in total

1.  Differentially Expressed Long Non-Coding RNAs Were Predicted to Be Involved in the Control of Signaling Pathways in Pediatric Astrocytoma.

Authors:  Ruth Ruiz Esparza-Garrido; Juan Manuel Rodríguez-Corona; Javier Enrique López-Aguilar; Marco Antonio Rodríguez-Florido; Ana Claudia Velázquez-Wong; Rubí Viedma-Rodríguez; Fabio Salamanca-Gómez; Miguel Ángel Velázquez-Flores
Journal:  Mol Neurobiol       Date:  2016-10-13       Impact factor: 5.590

2.  Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells.

Authors:  Zhen-Hua Chen; Hong-Kang Hu; Chen-Ran Zhang; Cheng-Yin Lu; Yi Bao; Zheng Cai; Yong-Xiang Zou; Guo-Han Hu; Lei Jiang
Journal:  Am J Transl Res       Date:  2016-10-15       Impact factor: 4.060

3.  MALAT1 in Human Adipose Stem Cells Modulates Survival and Alternative Splicing of PKCδII in HT22 Cells.

Authors:  Ghattas El Bassit; Rekha S Patel; Gay Carter; Vyshakh Shibu; Achintya A Patel; Shijie Song; Michel Murr; Denise R Cooper; Paula C Bickford; Niketa A Patel
Journal:  Endocrinology       Date:  2017-01-01       Impact factor: 4.736

4.  Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis.

Authors:  Zhijun Zhao; Bin Wang; Junhai Hao; Weitao Man; Yongkai Chang; Shunchang Ma; Yeshuai Hu; Fusheng Liu; Jun Yang
Journal:  Oncol Lett       Date:  2018-01-12       Impact factor: 2.967

5.  Differential lncRNA expression profiles in recurrent gliomas compared with primary gliomas identified by microarray analysis.

Authors:  Yi Chen; Jian-Jin Wu; Xian-Bin Lin; Yi Bao; Zhen-Hua Chen; Cheng-Ran Zhang; Zheng Cai; Jue-Yu Zhou; Mao-Hua Ding; Xiao-Jun Wu; Wei Sun; Jun Qian; Lei Zhang; Lei Jiang; Guo-Han Hu
Journal:  Int J Clin Exp Med       Date:  2015-04-15

Review 6.  Prognostic and clinicopathological significance of long non-coding RNA in glioma.

Authors:  Junhong Li; Ruofei Liang; Chen Song; Yufan Xiang; Yanhui Liu
Journal:  Neurosurg Rev       Date:  2018-03-21       Impact factor: 3.042

7.  DGCR8/ZFAT-AS1 Promotes CDX2 Transcription in a PRC2 Complex-Dependent Manner to Facilitate the Malignant Biological Behavior of Glioma Cells.

Authors:  Fangfang Zhang; Xuelei Ruan; Jun Ma; Xiaobai Liu; Jian Zheng; Yunhui Liu; Libo Liu; Shuyuan Shen; Lianqi Shao; Di Wang; Chunqing Yang; Heng Cai; Zhen Li; Ziyi Feng; Yixue Xue
Journal:  Mol Ther       Date:  2019-11-20       Impact factor: 11.454

8.  Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer.

Authors:  Bing Zhou; Xiao-Yue Jing; Jie-Qing Wu; Hui-Fang Xi; Guang-Jian Lu
Journal:  Int J Clin Exp Pathol       Date:  2014-12-01

Review 9.  A critical overview of long non-coding RNA in glioma etiology 2016: an update.

Authors:  Yuan-Feng Gao; Zhi-Bin Wang; Tao Zhu; Chen-Xue Mao; Xiao-Yuan Mao; Ling Li; Ji-Ye Yin; Hong-Hao Zhou; Zhao-Qian Liu
Journal:  Tumour Biol       Date:  2016-09-15

10.  LncRNA and mRNA expression profiles of glioblastoma multiforme (GBM) reveal the potential roles of lncRNAs in GBM pathogenesis.

Authors:  Qi Li; Hongmei Jia; Haowen Li; Chengya Dong; Yajie Wang; Zhongmei Zou
Journal:  Tumour Biol       Date:  2016-09-08
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