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Literature DB >> 25031433

Clinical significance of low-positive histoplasma urine antigen results.

Abstract

Histoplasma urine antigen (UAg) detection is an important biomarker for histoplasmosis. The clinical significance of low-positive (<0.6 ng/ml) UAg results was evaluated in 25 patients without evidence of prior Histoplasma infection. UAg results from 12/25 (48%) patients were considered falsely positive, suggesting that low-positive UAg values should be interpreted cautiously.

Entities: Disease Species

Mesh：

Substances：
Antigens, Fungal

Year: 2014 PMID： 25031433 PMCID： PMC4313180 DOI： 10.1128/JCM.01598-14

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

7 in total

1. Detection of Blastomyces dermatitidis and Histoplasma capsulatum from culture isolates and clinical specimens by use of real-time PCR.

Authors: N Esther Babady; Seanne P Buckwalter; Leslie Hall; Kara M Le Febre; Matthew J Binnicker; Nancy L Wengenack
Journal: J Clin Microbiol Date: 2011-07-13 Impact factor: 5.948

2. A multicenter evaluation of tests for diagnosis of histoplasmosis.

Authors: Chadi A Hage; Julie A Ribes; Nancy L Wengenack; Larry M Baddour; Maha Assi; David S McKinsey; Kassem Hammoud; Daisy Alapat; N Esther Babady; Michelle Parker; DeAnna Fuller; Aliya Noor; Thomas E Davis; Mark Rodgers; Patricia A Connolly; Boutros El Haddad; L Joseph Wheat
Journal: Clin Infect Dis Date: 2011-08-02 Impact factor: 9.079

3. DIAGNOSIS OF HISTOPLASMOSIS.

Authors: Allan Jefferson Guimarães; Joshua D Nosanchuk; Rosely Maria Zancopé-Oliveira
Journal: Braz J Microbiol Date: 2006-01 Impact factor: 2.476

Review 4. Antigen detection, serology, and molecular diagnosis of invasive mycoses in the immunocompromised host.

Authors: L J Wheat
Journal: Transpl Infect Dis Date: 2006-09 Impact factor: 2.228

5. Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay.

Authors: Chadi A Hage; Emily J Kirsch; Timothy E Stump; Carol A Kauffman; Mitchell Goldman; Patricia Connolly; Philip C Johnson; L Joseph Wheat; John W Baddley
Journal: Clin Vaccine Immunol Date: 2011-02-09

6. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America.

Authors: L Joseph Wheat; Alison G Freifeld; Martin B Kleiman; John W Baddley; David S McKinsey; James E Loyd; Carol A Kauffman
Journal: Clin Infect Dis Date: 2007-08-27 Impact factor: 9.079

7. Evaluation of an enzyme immunoassay for detection of Histoplasma capsulatum antigen from urine specimens.

Authors: Elitza S Theel; Deborah J Jespersen; Julie Harring; Jay Mandrekar; Matthew J Binnicker
Journal: J Clin Microbiol Date: 2013-08-21 Impact factor: 5.948

7 in total

6 in total

6. A monoclonal antibody-based urine Histoplasma antigen enzyme immunoassay (IMMY®) for the diagnosis of histoplasmosis in cats.

Authors: Lana Rothenburg; Andrew S Hanzlicek; Mark E Payton
Journal: J Vet Intern Med Date: 2018-12-17 Impact factor: 3.333

6 in total

Clinical significance of low-positive histoplasma urine antigen results.

1. Detection of Blastomyces dermatitidis and Histoplasma capsulatum from culture isolates and clinical specimens by use of real-time PCR.

2. A multicenter evaluation of tests for diagnosis of histoplasmosis.

3. DIAGNOSIS OF HISTOPLASMOSIS.

Review 4. Antigen detection, serology, and molecular diagnosis of invasive mycoses in the immunocompromised host.

5. Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay.

6. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America.

7. Evaluation of an enzyme immunoassay for detection of Histoplasma capsulatum antigen from urine specimens.

1. Reply to "Low-positive histoplasma antigen results in the MVista assay should not be assumed to be false positive".

2. Low-positive histoplasma antigen results in the MVista assay should not be assumed to be false positive.

Review 3. Updates in Laboratory Diagnostics for Invasive Fungal Infections.

Review 4. Laboratory Diagnostics for Histoplasmosis.

5. Antigen Concentrations as an Indicator of Clinical Remission and Disease Relapse in Cats with Histoplasmosis.

6. A monoclonal antibody-based urine Histoplasma antigen enzyme immunoassay (IMMY®) for the diagnosis of histoplasmosis in cats.