OBJECTIVE: To evaluate the diagnostic accuracy of a new diagnostic instrument for epilepsy - INCLEN Diagnostic Tool for Epilepsy (INDT-EPI) - with evaluation by expert pediatric neurologists. STUDY DESIGN: Evaluation of diagnostic test. SETTING: Tertiary care pediatric referral centers in India. METHODS: Children aged 2-9 years, enrolled by systematic random sampling at pediatric neurology out-patient clinics of three tertiary care centers were independently evaluated in a blinded manner by primary care physicians trained to administer the test, and by teams of two pediatric neurologists. OUTCOMES: A 13-item questionnaire administered by trained primary care physicians (candidate test) and comprehensive subject evaluation by pediatric neurologists (gold standard). RESULTS: There were 240 children with epilepsy and 274 without epilepsy. The candidate test for epilepsy had sensitivity and specificity of 85.8% and 95.3%; positive and negative predictive values of 94.0% and 88.5%; and positive and negative likelihood ratios of 18.25 and 0.15, respectively. CONCLUSIONS: The INDT-EPI has high validity to identify children with epilepsy when used by primary care physicians.
OBJECTIVE: To evaluate the diagnostic accuracy of a new diagnostic instrument for epilepsy - INCLEN Diagnostic Tool for Epilepsy (INDT-EPI) - with evaluation by expert pediatric neurologists. STUDY DESIGN: Evaluation of diagnostic test. SETTING: Tertiary care pediatric referral centers in India. METHODS:Children aged 2-9 years, enrolled by systematic random sampling at pediatric neurology out-patient clinics of three tertiary care centers were independently evaluated in a blinded manner by primary care physicians trained to administer the test, and by teams of two pediatric neurologists. OUTCOMES: A 13-item questionnaire administered by trained primary care physicians (candidate test) and comprehensive subject evaluation by pediatric neurologists (gold standard). RESULTS: There were 240 children with epilepsy and 274 without epilepsy. The candidate test for epilepsy had sensitivity and specificity of 85.8% and 95.3%; positive and negative predictive values of 94.0% and 88.5%; and positive and negative likelihood ratios of 18.25 and 0.15, respectively. CONCLUSIONS: The INDT-EPI has high validity to identify children with epilepsy when used by primary care physicians.
Authors: Joseph Nelson Siewe Fodjo; Marieke C J Dekker; Richard Idro; Michel Ndahura Mandro; Pierre-Marie Preux; Alfred K Njamnshi; Robert Colebunders Journal: Infect Dis Poverty Date: 2019-02-10 Impact factor: 4.520
Authors: Narendra K Arora; M K C Nair; Sheffali Gulati; Vaishali Deshmukh; Archisman Mohapatra; Devendra Mishra; Vikram Patel; Ravindra M Pandey; Bhagabati C Das; Gauri Divan; G V S Murthy; Thakur D Sharma; Savita Sapra; Satinder Aneja; Monica Juneja; Sunanda K Reddy; Praveen Suman; Sharmila B Mukherjee; Rajib Dasgupta; Poma Tudu; Manoja K Das; Vinod K Bhutani; Maureen S Durkin; Jennifer Pinto-Martin; Donald H Silberberg; Rajesh Sagar; Faruqueuddin Ahmed; Nandita Babu; Sandeep Bavdekar; Vijay Chandra; Zia Chaudhuri; Tanuj Dada; Rashna Dass; M Gourie-Devi; S Remadevi; Jagdish C Gupta; Kumud K Handa; Veena Kalra; Sunil Karande; Ramesh Konanki; Madhuri Kulkarni; Rashmi Kumar; Arti Maria; Muneer A Masoodi; Manju Mehta; Santosh Kumar Mohanty; Harikumaran Nair; Poonam Natarajan; A K Niswade; Atul Prasad; Sanjay K Rai; Paul S S Russell; Rohit Saxena; Shobha Sharma; Arun K Singh; Gautam B Singh; Leena Sumaraj; Saradha Suresh; Alok Thakar; Sujatha Parthasarathy; Bhadresh Vyas; Ansuman Panigrahi; Munish K Saroch; Rajan Shukla; K V Raghava Rao; Maria P Silveira; Samiksha Singh; Vivek Vajaratkar Journal: PLoS Med Date: 2018-07-24 Impact factor: 11.069