Literature DB >> 25030734

Renin inhibition improves the survival of mesenchymal stromal cells in a mouse model of myocardial infarction.

Federico Franchi1, Adachukwu Ezenekwe, Lukas Wellkamp, Karen M Peterson, Amir Lerman, Martin Rodriguez-Porcel.   

Abstract

The aim of this study was to determine if renin inhibition is able to improve the survival of transplanted stem cells in a mouse model of myocardial infarction. Myocardial infarction was induced in FVB/NJ inbred mice (n = 23). Bone marrow-derived mouse mesenchymal stromal cells (mMSCs, 3 × 10(5)) expressing the reporter gene firefly luciferase were delivered intramyocardially (n = 12) and monitored non-invasively by bioluminescence imaging. A group of these mice (n = 6) received aliskiren (15 mg/kg/day) via an osmotic pump implanted subcutaneously. The survival of mMSCs was significantly increased in those animals that received aliskiren leading to a significant improvement in systolic function after myocardial infarction. Histological analysis revealed a significant reduction in inflammation and collagen deposition in those mice that received aliskiren compared to controls. Renin inhibition of the ischemic myocardium is able to modulate the microenvironment improving the survival and efficacy of transplanted mMSCs in a mouse model of myocardial infarction.

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Year:  2014        PMID： 25030734      PMCID： PMC4978430          DOI： 10.1007/s12265-014-9575-3

Source DB:  PubMed          Journal:  J Cardiovasc Transl Res        ISSN： 1937-5387            Impact factor:   4.132


  29 in total

1.  Image-guided cardiac cell delivery using high-resolution small-animal ultrasound.

Authors:  Martin Rodriguez-Porcel; Olivier Gheysens; Ian Y Chen; Joseph C Wu; Sanjiv Sam Gambhir
Journal:  Mol Ther       Date:  2005-08-18       Impact factor: 11.454

2.  Direct renin inhibition: another weapon to modulate the renin-angiotensin system in postinfarction remodeling?

Authors:  Stefano Perlini; Francesco Salinaro; Maria Luisa Fonte
Journal:  Hypertension       Date:  2008-10-27       Impact factor: 10.190

3.  Long-term outcome of stem cell therapy for acute myocardial infarction: right results, wrong reasons.

Authors:  James S Forrester; Raj R Makkar; Eduardo Marbán
Journal:  J Am Coll Cardiol       Date:  2009-06-16       Impact factor: 24.094

4.  Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction.

Authors:  Scott D Solomon; Sung Hee Shin; Amil Shah; Hicham Skali; Akshay Desai; Lars Kober; Aldo P Maggioni; Jean L Rouleau; Roxzana Y Kelly; Allen Hester; John J V McMurray; Marc A Pfeffer
Journal:  Eur Heart J       Date:  2011-02-10       Impact factor: 29.983

5.  Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.

Authors:  Volker Schächinger; Sandra Erbs; Albrecht Elsässer; Werner Haberbosch; Rainer Hambrecht; Hans Hölschermann; Jiangtao Yu; Roberto Corti; Detlef G Mathey; Christian W Hamm; Tim Süselbeck; Birgit Assmus; Torsten Tonn; Stefanie Dimmeler; Andreas M Zeiher
Journal:  N Engl J Med       Date:  2006-09-21       Impact factor: 91.245

6.  Improved survival of mesenchymal stromal cell after hypoxia preconditioning: role of oxidative stress.

Authors:  Karen M Peterson; Abdelrahman Aly; Amir Lerman; Lilach O Lerman; Martin Rodriguez-Porcel
Journal:  Life Sci       Date:  2010-11-06       Impact factor: 5.037

7.  Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.

Authors:  Koen E A van der Bogt; Sonja Schrepfer; Jin Yu; Ahmad Y Sheikh; Grant Hoyt; Johannes A Govaert; Jeffrey B Velotta; Christopher H Contag; Robert C Robbins; Joseph C Wu
Journal:  Transplantation       Date:  2009-03-15       Impact factor: 4.939

8.  Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium.

Authors:  Martin Rodriguez-Porcel; Olivier Gheysens; Ramasamy Paulmurugan; Ian Y Chen; Karen M Peterson; Jürgen K Willmann; Joseph C Wu; Xiangyang Zhu; Lilach O Lerman; Sanjiv S Gambhir
Journal:  Mol Imaging Biol       Date:  2009-12-15       Impact factor: 3.488

9.  A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

Authors:  Joshua M Hare; Jay H Traverse; Timothy D Henry; Nabil Dib; Robert K Strumpf; Steven P Schulman; Gary Gerstenblith; Anthony N DeMaria; Ali E Denktas; Roger S Gammon; James B Hermiller; Mark A Reisman; Gary L Schaer; Warren Sherman
Journal:  J Am Coll Cardiol       Date:  2009-12-08       Impact factor: 24.094

Review 10.  Cardiac cell repair therapy: a clinical perspective.

Authors:  Bernard J Gersh; Robert D Simari; Atta Behfar; Carmen M Terzic; Andre Terzic
Journal:  Mayo Clin Proc       Date:  2009-10       Impact factor: 7.616
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  3 in total

1.  Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells.

Authors:  Federico Franchi; Karen M Peterson; Ramasamy Paulmurugan; Clifford Folmes; Ian R Lanza; Amir Lerman; Martin Rodriguez-Porcel
Journal:  Mol Imaging Biol       Date:  2016-08       Impact factor: 3.488

2.  Noninvasive Assessment of Cell Fate and Biology in Transplanted Mesenchymal Stem Cells.

Authors:  Federico Franchi; Martin Rodriguez-Porcel
Journal:  Methods Mol Biol       Date:  2017

3.  Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.

Authors:  Federico Franchi; Karen M Peterson; Katherine Quandt; David Domnick; Timothy L Kline; Michaela Olthoff; Mojtaba Parvizi; Ezequiel J Tolosa; Vicente E Torres; Peter C Harris; Martin E Fernandez-Zapico; Martin G Rodriguez-Porcel
Journal:  Hypertension       Date:  2020-10-05       Impact factor: 10.190
  3 in total

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