Literature DB >> 25030504

Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis.

M Kakeda1, Christoph Schlapbach, G Danelon, M M Tang, V Cecchinato, N Yawalkar, M Uguccioni.   

Abstract

Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP.

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Year:  2014        PMID： 25030504     DOI： 10.1007/s00403-014-1488-0

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  11 in total

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5.  Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

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6.  C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.

Authors:  Quan-You Zheng; Shen-Ju Liang; Feng Xu; Gui-Qing Li; Na Luo; Shun Wu; You Li; Ming Tang; Yu Zhong; Jian Chen; Di Yang; Dao-Dong Sun; Ke-Qin Zhang; Gui-Lian Xu
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7.  Ixekizumab for treatment of refractory acute generalized exanthematous pustulosis caused by hydroxychloroquine.

Authors:  Mohammad Munshi; Alexandra Junge; Karolina Gadaldi; Nikhil Yawalkar; Kristine Heidemeyer
Journal:  JAAD Case Rep       Date:  2020-05-17

8.  Case Report: Successful Treatment of Acute Generalized Exanthematous Pustulosis With Secukinumab.

Authors:  Liangliang Zhang; Qiuyun Xu; Tingting Lin; Shifan Ruan; Mengting Lin; Chengbei Bao; Jing Zhang; Tao Liu; Ting Gong; Chao Ji
Journal:  Front Med (Lausanne)       Date:  2021-12-16

Review 9.  Drug triggered pruritus, rash, papules, and blisters - is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?

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Journal:  Lipids Health Dis       Date:  2021-11-08       Impact factor: 3.876

10.  A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It.

Authors:  Nicola Tamassia; Fabio Arruda-Silva; Federica Calzetti; Silvia Lonardi; Sara Gasperini; Elisa Gardiman; Francisco Bianchetto-Aguilera; Luisa Benerini Gatta; Giampiero Girolomoni; Alberto Mantovani; William Vermi; Marco A Cassatella
Journal:  Front Immunol       Date:  2018-04-17       Impact factor: 7.561
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