| Literature DB >> 25030082 |
Edward J Cochrane1, Daniele Leonori, Lorraine A Hassall, Iain Coldham.
Abstract
The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97 : 3. On lithiation then electrophilic quench, 2,2-disubstituted piperidines were obtained with excellent yields and enantioselectivities.Entities:
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Year: 2014 PMID： 25030082 DOI： 10.1039/c4cc04576a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222