Tianpeng Zheng1, Yun Gao, Attit Baskota, Tao Chen, Xingwu Ran, Haoming Tian. 1. Department of Endocrinology and Metabolism (T.Z., Y.G., A.B., T.C., X.R., H.T.), West China Hospital of Sichuan University, Sichuan 610041, People's Republic of China; and Department of Endocrinology and Metabolism (T.Z.), Affiliated Hospital of Guilin Medical University, Guangxi 541001, People's Republic of China.
Abstract
CONTEXT: The significance of associations between prediabetes, type 2 diabetes, and dipeptidyl peptidase-4 (DPP4) activity in a Chinese population is not clear. OBJECTIVE: The objective of the study was to determine whether DPP4 activity and active glucagon-like peptide-1 (GLP-1) were predictive of the onset of prediabetes and type 2 diabetes. DESIGN, SETTING, AND PATIENTS: This was a 4-year follow-up study conducted in Sichuan, China. A total of 474 Chinese women and men aged 18-70 years were studied. MAIN OUTCOME MEASURES: All subjects were divided into 3 groups (normal glucose tolerance, prediabetes, and type 2 diabetes) on the basis of their glucose metabolism status after 4 years. The DPP4 activity, active GLP-1, and glucagon were measured at baseline and 4 years later. RESULTS: The baseline DPP4 activity was significantly higher in subjects who had progressed to prediabetes or type 2 diabetes compared with subjects who remained normoglycemic (P < .01). In a multiple linear regression analysis, baseline DPP4 activity and active GLP-1 were independent predictors of an increase in insulin resistance over a 4-year period (P < .05). Cox proportional hazards models revealed that DPP4 activity independently predicted the risk of developing prediabetes [relative risk 2.77 (95% confidence interval 1.38-5.55), P < .01] and type 2 diabetes [5.10 (95% confidence interval 1.48-17.61), P < .05] after adjustment for confounding risk factors. CONCLUSIONS: DPP4 activity is an important predictor of the onset of insulin resistance, prediabetes, and type 2 diabetes in apparently healthy Chinese individuals. This finding may have important implications for understanding the etiology of diabetes.
CONTEXT: The significance of associations between prediabetes, type 2 diabetes, and dipeptidyl peptidase-4 (DPP4) activity in a Chinese population is not clear. OBJECTIVE: The objective of the study was to determine whether DPP4 activity and active glucagon-like peptide-1 (GLP-1) were predictive of the onset of prediabetes and type 2 diabetes. DESIGN, SETTING, AND PATIENTS: This was a 4-year follow-up study conducted in Sichuan, China. A total of 474 Chinese women and men aged 18-70 years were studied. MAIN OUTCOME MEASURES: All subjects were divided into 3 groups (normal glucose tolerance, prediabetes, and type 2 diabetes) on the basis of their glucose metabolism status after 4 years. The DPP4 activity, active GLP-1, and glucagon were measured at baseline and 4 years later. RESULTS: The baseline DPP4 activity was significantly higher in subjects who had progressed to prediabetes or type 2 diabetes compared with subjects who remained normoglycemic (P < .01). In a multiple linear regression analysis, baseline DPP4 activity and active GLP-1 were independent predictors of an increase in insulin resistance over a 4-year period (P < .05). Cox proportional hazards models revealed that DPP4 activity independently predicted the risk of developing prediabetes [relative risk 2.77 (95% confidence interval 1.38-5.55), P < .01] and type 2 diabetes [5.10 (95% confidence interval 1.48-17.61), P < .05] after adjustment for confounding risk factors. CONCLUSIONS:DPP4 activity is an important predictor of the onset of insulin resistance, prediabetes, and type 2 diabetes in apparently healthy Chinese individuals. This finding may have important implications for understanding the etiology of diabetes.
Authors: Wellington Santana da Silva Júnior; Amélio Fernando de Godoy-Matos; Luiz Guilherme Kraemer-Aguiar Journal: Biomed Res Int Date: 2015-06-04 Impact factor: 3.411
Authors: Gilberto Vargas-Alarcón; María Del Carmen González-Salazar; Christian Vázquez-Vázquez; Adrián Hernández-Díaz Couder; Fausto Sánchez-Muñoz; Juan Reyes-Barrera; Sergio A Criales-Vera; Marco Sánchez-Guerra; Citlalli Osorio-Yáñez; Rosalinda Posadas-Sánchez Journal: Front Genet Date: 2021-06-11 Impact factor: 4.599