Literature DB >> 2502939

Central nervous system manifestations of a valproic acid overdose responsive to naloxone.

G Alberto1, T Erickson, R Popiel, M Narayanan, D Hryhorczuk.   

Abstract

We report the case of a 22-year-old man who presented with a depressed level of consciousness after ingesting valproic acid. He responded to IV naloxone; over a nine-hour period, his serum valproic acid level decreased from 180.4 to 59.2 micrograms/ml with multiple-dose charcoal therapy. We recommend the use of both agents in the treatment of valproic acid overdose.

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Year:  1989        PMID: 2502939     DOI: 10.1016/s0196-0644(89)80220-3

Source DB:  PubMed          Journal:  Ann Emerg Med        ISSN: 0196-0644            Impact factor:   5.721


  2 in total

Review 1.  Management of opioid analgesic overdose.

Authors:  Edward W Boyer
Journal:  N Engl J Med       Date:  2012-07-12       Impact factor: 91.245

Review 2.  Lesson of the month 1: Sodium valproate-induced encephalopathy.

Authors:  Lara Camilleri
Journal:  Clin Med (Lond)       Date:  2018-10       Impact factor: 2.659

  2 in total

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