BACKGROUND: The role of liver transplantation (LT) in the management of cirrhotic patients with tumors exhibiting intrahepatic bile duct differentiation remains controversial. The objective of this study was to characterize the spectrum of these tumors and analyze post-LT outcomes. METHODS: Retrospective pathology database search of explant histology analysis of liver transplants between April 1993 and November 2013. RESULTS: Thirty-two patients were analyzed, 75% were men with a mean age of 60 years. Seven patients had nodules demonstrating intrahepatic cholangiocarcinoma (I-CCA), nine had I-CCA nodules occurring concomitantly with hepatocellular carcinoma (HCC), and 16 had mixed HCC-CCA nodules. The median number of tumors was 1 and size was 2.5 cm. Overall patient survival post-LT at 1 and 5 years was 71% and 57%, respectively. Patients within Milan criteria, especially with I-CCA features, showed a 5-year tumor recurrence rate (10%) and 5-year survival rate (78%) comparable with other patients having HCC within Milan criteria. CONCLUSION: This series showed that patients with CCA within Milan criteria may be able to achieve acceptable long-term post-LT survival.
BACKGROUND: The role of liver transplantation (LT) in the management of cirrhoticpatients with tumors exhibiting intrahepatic bile duct differentiation remains controversial. The objective of this study was to characterize the spectrum of these tumors and analyze post-LT outcomes. METHODS: Retrospective pathology database search of explant histology analysis of liver transplants between April 1993 and November 2013. RESULTS: Thirty-two patients were analyzed, 75% were men with a mean age of 60 years. Seven patients had nodules demonstrating intrahepatic cholangiocarcinoma (I-CCA), nine had I-CCA nodules occurring concomitantly with hepatocellular carcinoma (HCC), and 16 had mixed HCC-CCA nodules. The median number of tumors was 1 and size was 2.5 cm. Overall patient survival post-LT at 1 and 5 years was 71% and 57%, respectively. Patients within Milan criteria, especially with I-CCA features, showed a 5-year tumor recurrence rate (10%) and 5-year survival rate (78%) comparable with other patients having HCC within Milan criteria. CONCLUSION: This series showed that patients with CCA within Milan criteria may be able to achieve acceptable long-term post-LT survival.
Authors: Ka Wing Ma; Kenneth Siu Ho Chok; Wong Hoi She; Tan To Cheung; Albert Chi Yan Chan; Wing Chiu Dai; James Yan Yue Fung; Chung Mau Lo Journal: Hepatol Int Date: 2018-02-15 Impact factor: 6.047
Authors: Leigh Anne Dageforde; Neeta Vachharajani; Parissa Tabrizian; Vatche Agopian; Karim Halazun; Erin Maynard; Kristopher Croome; David Nagorney; Johnny C Hong; David Lee; Cristina Ferrone; Erin Baker; William Jarnagin; Alan Hemming; Gabriel Schnickel; Shoko Kimura; Ronald Busuttil; Jessica Lindemann; Sander Florman; Matthew L Holzner; Rami Srouji; Marc Najjar; Lavanya Yohanathan; Jane Cheng; Hiral Amin; Charles A Rickert; Ju Dong Yang; Joohyun Kim; Jennifer Pasko; William C Chapman; Maria B Majella Doyle Journal: J Am Coll Surg Date: 2020-12-13 Impact factor: 6.113