Literature DB >> 25029354

Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions.

Claudia Crescio1, Marco Orecchioni, Cécilia Ménard-Moyon, Francesco Sgarrella, Proto Pippia, Roberto Manetti, Alberto Bianco, Lucia Gemma Delogu.   

Abstract

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

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Year:  2014        PMID： 25029354     DOI： 10.1039/c4nr02711f

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  5 in total

Review 1.  Graphene as cancer theranostic tool: progress and future challenges.

Authors:  Marco Orecchioni; Roberto Cabizza; Alberto Bianco; Lucia Gemma Delogu
Journal:  Theranostics       Date:  2015-03-28       Impact factor: 11.556

2.  Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol.

Authors:  Cristiano Farace; Paola Sánchez-Moreno; Marco Orecchioni; Roberto Manetti; Francesco Sgarrella; Yolande Asara; José M Peula-García; Juan A Marchal; Roberto Madeddu; Lucia G Delogu
Journal:  Sci Rep       Date:  2016-01-05       Impact factor: 4.379

3.  Evaluation of the immunological profile of antibody-functionalized metal-filled single-walled carbon nanocapsules for targeted radiotherapy.

Authors:  Aritz Perez Ruiz de Garibay; Cinzia Spinato; Rebecca Klippstein; Maxime Bourgognon; Markus Martincic; Elzbieta Pach; Belén Ballesteros; Cécilia Ménard-Moyon; Khuloud T Al-Jamal; Gerard Tobias; Alberto Bianco
Journal:  Sci Rep       Date:  2017-02-15       Impact factor: 4.379

4.  An Immunologically Modified Nanosystem Based on Noncovalent Binding Between Single-Walled Carbon Nanotubes and Glycated Chitosan.

Authors:  Leton Chandra Saha; Okhil Kumar Nag; Austin Doughty; Hong Liu; Wei R Chen
Journal:  Technol Cancer Res Treat       Date:  2018-01-01

5.  Bioinspired Scaffold Action Under the Extreme Physiological Conditions of Simulated Space Flights: Osteogenesis Enhancing Under Microgravity.

Authors:  Elisabetta Avitabile; Laura Fusco; Silvia Minardi; Marco Orecchioni; Barbara Zavan; Acelya Yilmazer; Martina Rauner; Proto Pippia; Ennio Tasciotti; Lucia Gemma Delogu
Journal:  Front Bioeng Biotechnol       Date:  2020-07-08
  5 in total

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