| Literature DB >> 25028498 |
Johannes Grosse1, Helen Heffron1, Keith Burling2, Mohammed Akhter Hossain3, Abdella M Habib4, Gareth J Rogers4, Paul Richards5, Rachel Larder6, Debra Rimmington6, Alice A Adriaenssens5, Laura Parton1, Justin Powell1, Matteo Binda7, William H Colledge8, Joanne Doran1, Yukio Toyoda9, John D Wade3, Samuel Aparicio10, Mark B L Carlton1, Anthony P Coll6, Frank Reimann5, Stephen O'Rahilly11, Fiona M Gribble5.
Abstract
The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-like peptide-1 and peptideYY. i.p. Insl5 increased food intake in wild-type mice but not mice lacking the cognate receptor Rxfp4. Plasma Insl5 levels were elevated by fasting or prolonged calorie restriction, and declined with feeding. We conclude that Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation.Entities:
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Year: 2014 PMID： 25028498 PMCID： PMC4121845 DOI： 10.1073/pnas.1411413111
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205