Wouter Stomp1, Annemarie Krabben2, Désirée van der Heijde2, Tom W J Huizinga2, Johan L Bloem2, Annette H M van der Helm-van Mil2, Monique Reijnierse2. 1. From the Department of Radiology, and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.W. Stomp, Researcher, MD, Department of Radiology, Leiden University Medical Center; A. Krabben, Researcher, MD; D. van der Heijde, Professor of Rheumatology, MD, PhD; T.W.J. Huizinga, Professor of Rheumatology, MD, PhD, Department of Rheumatology, Leiden University Medical Center; J.L. Bloem, Professor of Radiology, MD, PhD, Department of Radiology; A.H.M. van der Helm-van Mil, Rheumatologist, MD, PhD, Department of Rheumatology; M. Reijnierse, Radiologist, MD, PhD, Department of Radiology, Leiden University Medical Center. w.stomp@lumc.nl. 2. From the Department of Radiology, and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.W. Stomp, Researcher, MD, Department of Radiology, Leiden University Medical Center; A. Krabben, Researcher, MD; D. van der Heijde, Professor of Rheumatology, MD, PhD; T.W.J. Huizinga, Professor of Rheumatology, MD, PhD, Department of Rheumatology, Leiden University Medical Center; J.L. Bloem, Professor of Radiology, MD, PhD, Department of Radiology; A.H.M. van der Helm-van Mil, Rheumatologist, MD, PhD, Department of Rheumatology; M. Reijnierse, Radiologist, MD, PhD, Department of Radiology, Leiden University Medical Center.
Abstract
OBJECTIVE: Magnetic resonance imaging (MRI) is increasingly used in rheumatoid arthritis (RA) research. A European League Against Rheumatism (EULAR) task force recently suggested that MRI can improve the certainty of RA diagnosis. Because this recommendation may reflect a tendency to use MRI in daily practice, thorough studies on the value of MRI are required. Thus far no large studies have evaluated the accuracy of MRI to differentiate early RA from other patients with early arthritis. We performed a large cross-sectional study to determine whether patients who are clinically classified with RA differ in MRI features compared to patients with other diagnoses. METHODS: In our study, 179 patients presenting with early arthritis (median symptom duration 15.4 weeks) underwent 1.5T extremity MRI of unilateral wrist, metacarpophalangeal, and metatarsophalangeal joints according to our arthritis protocol, the foot without contrast. Images were scored according to OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Scoring (RAMRIS) by 2 independent readers. Tenosynovitis was also assessed. The main outcome was fulfilling the 1987 American College of Rheumatology (ACR) criteria for RA. Test characteristics and areas under the receiver-operator-characteristic curves (AUC) were evaluated. In subanalyses, the 2010 ACR/EULAR criteria were used as outcome, and analyses were stratified for anticitrullinated protein antibodies (ACPA). RESULTS: The ACR 1987 criteria were fulfilled in 43 patients (24.0%). Patients with RA had higher scores for synovitis, tenosynovitis, and bone marrow edema (BME) than patients without RA (p < 0.05). ACPA-positive patients had more BME (median scores 6.5 vs. 4.25, p = 0.016) than ACPA-negative patients. For all MRI features, the predictive value for the presence of RA was low (< 50%). For all MRI features the AUC were < 0.70. Patients who fulfilled ACR/EULAR 2010 criteria but not ACR87 criteria for RA had less synovitis than patients who were positive for RA according to both sets of criteria (p = 0.029). CONCLUSION: Although patients with RA had higher scores of MRI inflammation and ACPA-positive patients had more BME, the severity of MRI inflammation assessed according to RAMRIS does not accurately differentiate patients with RA from other early arthritis patients.
OBJECTIVE: Magnetic resonance imaging (MRI) is increasingly used in rheumatoid arthritis (RA) research. A European League Against Rheumatism (EULAR) task force recently suggested that MRI can improve the certainty of RA diagnosis. Because this recommendation may reflect a tendency to use MRI in daily practice, thorough studies on the value of MRI are required. Thus far no large studies have evaluated the accuracy of MRI to differentiate early RA from other patients with early arthritis. We performed a large cross-sectional study to determine whether patients who are clinically classified with RA differ in MRI features compared to patients with other diagnoses. METHODS: In our study, 179 patients presenting with early arthritis (median symptom duration 15.4 weeks) underwent 1.5T extremity MRI of unilateral wrist, metacarpophalangeal, and metatarsophalangeal joints according to our arthritis protocol, the foot without contrast. Images were scored according to OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Scoring (RAMRIS) by 2 independent readers. Tenosynovitis was also assessed. The main outcome was fulfilling the 1987 American College of Rheumatology (ACR) criteria for RA. Test characteristics and areas under the receiver-operator-characteristic curves (AUC) were evaluated. In subanalyses, the 2010 ACR/EULAR criteria were used as outcome, and analyses were stratified for anticitrullinated protein antibodies (ACPA). RESULTS: The ACR 1987 criteria were fulfilled in 43 patients (24.0%). Patients with RA had higher scores for synovitis, tenosynovitis, and bone marrow edema (BME) than patients without RA (p < 0.05). ACPA-positive patients had more BME (median scores 6.5 vs. 4.25, p = 0.016) than ACPA-negative patients. For all MRI features, the predictive value for the presence of RA was low (< 50%). For all MRI features the AUC were < 0.70. Patients who fulfilled ACR/EULAR 2010 criteria but not ACR87 criteria for RA had less synovitis than patients who were positive for RA according to both sets of criteria (p = 0.029). CONCLUSION: Although patients with RA had higher scores of MRI inflammation and ACPA-positive patients had more BME, the severity of MRI inflammation assessed according to RAMRIS does not accurately differentiate patients with RA from other early arthritispatients.
Entities:
Keywords:
ARTHRITIS; MAGNETIC RESONANCE IMAGING; METACARPUS; METATARSUS; RHEUMATOID ARTHRITIS; WRIST
Authors: Wouter Stomp; Annemarie Krabben; Désirée van der Heijde; Tom W J Huizinga; Johan L Bloem; Mikkel Østergaard; Annette H M van der Helm-van Mil; Monique Reijnierse Journal: Eur Radiol Date: 2015-01-31 Impact factor: 5.315
Authors: Debbie M Boeters; Wouter P Nieuwenhuis; Marije K Verheul; Elize C Newsum; Monique Reijnierse; René E M Toes; Leendert A Trouw; Annette H M van der Helm-van Mil Journal: Arthritis Res Ther Date: 2016-08-02 Impact factor: 5.156
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Authors: Marina Carotti; Vittoria Galeazzi; Francesca Catucci; Marcello Zappia; Francesco Arrigoni; Antonio Barile; Andrea Giovagnoni Journal: Acta Biomed Date: 2018-01-19