Abdullah Kisaoglu1, Bunyami Ozogul1, Mehmet Ibrahim Turan2, Ismayil Yilmaz3, Ismail Demiryilmaz4, Sabri Selcuk Atamanalp1, Ebubekir Bakan5, Halis Suleyman6. 1. Department of General Surgery, Ataturk University, Erzurum, Turkey. 2. Department of Pediatric Neurology, Diyarbakir Research and Educational Hospital, Diyarbakir, Turkey. Electronic address: turan78tr@hotmail.com. 3. Department of General Surgery, Erzincan University, Erzincan, Turkey. 4. Department of General Surgery, Ibni Sina Hospital, Kayseri, Turkey. 5. Department of Biochemistry, Ataturk University, Erzurum, Turkey. 6. Department of Pharmacology, Recep Tayyip Erdogan University, Rize, Turkey.
Abstract
BACKGROUND: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. METHODS: Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. RESULTS: The results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. CONCLUSION: Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity.
BACKGROUND: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. METHODS:Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. RESULTS: The results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. CONCLUSION:Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamolhepatotoxicity. These findings show that TPP may be beneficial in paracetamolhepatotoxicity.