Literature DB >> 25027733

Noncoding RNAs in the regulation of DNA replication.

Xin Quan Ge1, Haifan Lin2.   

Abstract

Noncoding RNAs (ncRNAs) have crucial roles in epigenetic, transcriptional, and post-transcriptional regulation. Recent studies have begun to reveal a role of ncRNAs in DNA replication. Here, we review the roles of ncRNAs in regulating different aspects of DNA replication in prokaryotic and eukaryotic systems. We speculate that ncRNAs might function to guide the origin recognition complex (ORC) to chromosomal DNA during replication initiation in higher eukaryotes.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DNA replication; ORC; miRNA; noncoding RNA; primer

Mesh:

Substances:

Year:  2014        PMID: 25027733      PMCID: PMC4265214          DOI: 10.1016/j.tibs.2014.06.003

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN: 0968-0004            Impact factor:   13.807


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