P Waliszewski1, F Wagenlehner, S Gattenlöhner, W Weidner. 1. Klinik für Urologie, Andrologie und Kinderurologie, Justus-Liebig-Universität, Rudolf-Buchheim-Straße 7, 35392, Gießen, Deutschland, complexityresearch@yahoo.com.
Abstract
BACKGROUND: A possible approach to objectively classify complex patterns in tumor tissue is a mathematical and statistical investigation of the distribution of cell nuclei as a geometric representation of cancer cells by fractal dimensions. Both the existence and changes in the fractal structure of tumor tissue have important consequences for the objective system of tumor grading. In addition, the complexity of growth in different carcinomas or their intercellular interactions can be compared to each other. RESULTS: We present a theoretical introduction into fractal geometry as well as in the computer algorithms based upon the Rényi family of fractal dimensions. Finally, a geometric model of prostate cancer is introduced and the relationship between geometric patterns of prostate tumor and the fractal dimensions of the Rényi family are explained.
BACKGROUND: A possible approach to objectively classify complex patterns in tumor tissue is a mathematical and statistical investigation of the distribution of cell nuclei as a geometric representation of cancer cells by fractal dimensions. Both the existence and changes in the fractal structure of tumor tissue have important consequences for the objective system of tumor grading. In addition, the complexity of growth in different carcinomas or their intercellular interactions can be compared to each other. RESULTS: We present a theoretical introduction into fractal geometry as well as in the computer algorithms based upon the Rényi family of fractal dimensions. Finally, a geometric model of prostate cancer is introduced and the relationship between geometric patterns of prostate tumor and the fractal dimensions of the Rényi family are explained.
Authors: Markus Loeffler; Lars Greulich; Patrick Scheibe; Philip Kahl; David Adler; Ulf-Dietrich Braumann; Jens-Peer Kuska; Nicolas Wernert Journal: J Urol Date: 2012-03-16 Impact factor: 7.450