Literature DB >> 25027376

Genetic variations of bile salt transporters.

Ralf Kubitz, Carola Dröge, Stefanie Kluge, Jan Stindt, Dieter Häussinger.   

Abstract

Bile salt transporters directly or indirectly influence biological processes through physicochemical or signalling properties of bile salts. The coordinated action of uptake and efflux transporters in polarized epithelial cells of the liver, biliary tree, small intestine and kidney determine bile salt concentrations in different compartments of the body. Genetic variations of bile salt transporters lead to clinical relevant phenotypes of varying severity ranging from a predisposition for drug-induced liver injury to rapidly progressing end-stage liver disease. This review focuses on the impact of genetic variations of bile salt transporters including BSEP, NTCP, ASBT and OSTα/β and discusses approaches for transporter analysis.

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Year:  2014        PMID： 25027376     DOI： 10.1016/j.ddtec.2014.03.006

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  6 in total

Review 1.  Intestinal Absorption of Bile Acids in Health and Disease.

Authors:  Alexander L Ticho; Pooja Malhotra; Pradeep K Dudeja; Ravinder K Gill; Waddah A Alrefai
Journal:  Compr Physiol       Date:  2019-12-18       Impact factor: 9.090

2.  Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.

Authors:  Roman Tremmel; Anne T Nies; Barbara A C van Eijck; Niklas Handin; Mathias Haag; Stefan Winter; Florian A Büttner; Charlotte Kölz; Franziska Klein; Pascale Mazzola; Ute Hofmann; Kathrin Klein; Per Hoffmann; Markus M Nöthen; Fabienne Z Gaugaz; Per Artursson; Matthias Schwab; Elke Schaeffeler
Journal:  Int J Mol Sci       Date:  2022-07-05       Impact factor: 6.208

3.  The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease.

Authors:  Kazuya Okushin; Takeya Tsutsumi; Kenichiro Enooku; Hidetaka Fujinaga; Akira Kado; Junji Shibahara; Masashi Fukayama; Kyoji Moriya; Hiroshi Yotsuyanagi; Kazuhiko Koike
Journal:  J Gastroenterol       Date:  2015-11-25       Impact factor: 7.527

4.  Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone.

Authors:  Lang Gan; Shuguang Pan; Jinchi Cui; Jie Bai; Peng Jiang; Yu He
Journal:  Mol Med Rep       Date:  2018-11-15       Impact factor: 2.952

5.  Exon-skipping and mRNA decay in human liver tissue: molecular consequences of pathogenic bile salt export pump mutations.

Authors:  Carola Dröge; Heiner Schaal; Guido Engelmann; Daniel Wenning; Dieter Häussinger; Ralf Kubitz
Journal:  Sci Rep       Date:  2016-04-26       Impact factor: 4.379

6.  Role of polymorphic bile salt export pump (BSEP, ABCB11) transporters in anti-tuberculosis drug-induced liver injury in a Chinese cohort.

Authors:  Ru Chen; Jing Wang; Shaowen Tang; Yuan Zhang; Xiaozhen Lv; Shanshan Wu; Zhirong Yang; Yinyin Xia; Dafang Chen; Siyan Zhan
Journal:  Sci Rep       Date:  2016-06-13       Impact factor: 4.379
  6 in total

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