Literature DB >> 25026207

RhoA mutations identified in diffuse gastric cancer.

Jin Zhou1, Yoku Hayakawa2, Timothy C Wang3, Adam J Bass4.   

Abstract

The diffuse-type histologic variant of gastric cancer is characterized by highly invasive growth patterns and lack of cellular cohesion. Two recent studies have identified highly recurrent mutations of the gene encoding the small GTPase RhoA and suggest that RhoA activity may have a tumor suppressive role in this disease.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25026207      PMCID： PMC4206186          DOI： 10.1016/j.ccr.2014.06.022

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.

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Journal:  EMBO J       Date:  1998-03-02       Impact factor: 11.598

2.  E-cadherin germline mutations in familial gastric cancer.

Authors:  P Guilford; J Hopkins; J Harraway; M McLeod; N McLeod; P Harawira; H Taite; R Scoular; A Miller; A E Reeve
Journal:  Nature       Date:  1998-03-26       Impact factor: 49.962

3.  A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.

Authors:  Hae Yong Yoo; Min Kyung Sung; Seung Ho Lee; Sangok Kim; Haeseung Lee; Seongjin Park; Sang Cheol Kim; Byungwook Lee; Kyoohyoung Rho; Jong-Eun Lee; Kwang-Hwi Cho; Wankyu Kim; Hyunjung Ju; Jaesang Kim; Seok Jin Kim; Won Seog Kim; Sanghyuk Lee; Young Hyeh Ko
Journal:  Nat Genet       Date:  2014-03-02       Impact factor: 38.330

4.  Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.

Authors:  Miwako Kakiuchi; Takashi Nishizawa; Hiroki Ueda; Kengo Gotoh; Atsushi Tanaka; Akimasa Hayashi; Shogo Yamamoto; Kenji Tatsuno; Hiroto Katoh; Yoshiaki Watanabe; Takashi Ichimura; Tetsuo Ushiku; Shinichi Funahashi; Keisuke Tateishi; Ikuo Wada; Nobuyuki Shimizu; Sachiyo Nomura; Kazuhiko Koike; Yasuyuki Seto; Masashi Fukayama; Hiroyuki Aburatani; Shumpei Ishikawa
Journal:  Nat Genet       Date:  2014-05-11       Impact factor: 38.330

5.  Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

Authors:  T Joneson; M A White; M H Wigler; D Bar-Sagi
Journal:  Science       Date:  1996-02-09       Impact factor: 47.728

Review 6.  Rho GTPase function in tumorigenesis.

Authors:  R Karlsson; E D Pedersen; Z Wang; Cord Brakebusch
Journal:  Biochim Biophys Acta       Date:  2009-03-24

7.  E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells.

Authors:  S S Kantak; R H Kramer
Journal:  J Biol Chem       Date:  1998-07-03       Impact factor: 5.157

8.  Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.

Authors:  Mamiko Sakata-Yanagimoto; Terukazu Enami; Kenichi Yoshida; Yuichi Shiraishi; Ryohei Ishii; Yasuyuki Miyake; Hideharu Muto; Naoko Tsuyama; Aiko Sato-Otsubo; Yusuke Okuno; Seiji Sakata; Yuhei Kamada; Rie Nakamoto-Matsubara; Nguyen Bich Tran; Koji Izutsu; Yusuke Sato; Yasunori Ohta; Junichi Furuta; Seiichi Shimizu; Takuya Komeno; Yuji Sato; Takayoshi Ito; Masayuki Noguchi; Emiko Noguchi; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Kazumi Suzukawa; Toru Nanmoku; Yuichi Hasegawa; Osamu Nureki; Satoru Miyano; Naoya Nakamura; Kengo Takeuchi; Seishi Ogawa; Shigeru Chiba
Journal:  Nat Genet       Date:  2014-01-12       Impact factor: 41.307

9.  Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.

Authors:  Teresa Palomero; Lucile Couronné; Hossein Khiabanian; Mi-Yeon Kim; Alberto Ambesi-Impiombato; Arianne Perez-Garcia; Zachary Carpenter; Francesco Abate; Maddalena Allegretta; J Erika Haydu; Xiaoyu Jiang; Izidore S Lossos; Concha Nicolas; Milagros Balbin; Christian Bastard; Govind Bhagat; Miguel A Piris; Elias Campo; Olivier A Bernard; Raul Rabadan; Adolfo A Ferrando
Journal:  Nat Genet       Date:  2014-01-12       Impact factor: 41.307

10.  Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.

Authors:  Kai Wang; Siu Tsan Yuen; Jiangchun Xu; Siu Po Lee; Helen H N Yan; Stephanie T Shi; Hoi Cheong Siu; Shibing Deng; Kent Man Chu; Simon Law; Kok Hoe Chan; Annie S Y Chan; Wai Yin Tsui; Siu Lun Ho; Anthony K W Chan; Jonathan L K Man; Valentina Foglizzo; Man Kin Ng; April S Chan; Yick Pang Ching; Grace H W Cheng; Tao Xie; Julio Fernandez; Vivian S W Li; Hans Clevers; Paul A Rejto; Mao Mao; Suet Yi Leung
Journal:  Nat Genet       Date:  2014-05-11       Impact factor: 38.330
  10 in total
  22 in total

1.  Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.

Authors:  Alireza Korourian; Raheleh Roudi; Ahmad Shariftabrizi; Elham Kalantari; Kambiz Sotoodeh; Zahra Madjd
Journal:  Clin Exp Med       Date:  2016-12-01       Impact factor: 3.984

Review 2.  Potentially Curable Cancers of the Esophagus and Stomach.

Authors:  Elena Elimova; Dilsa Mizrak Kaya; Kazuto Harada; Jaffer A Ajani
Journal:  Mayo Clin Proc       Date:  2016-09       Impact factor: 7.616

Review 3.  Targeting the cytoskeleton against metastatic dissemination.

Authors:  Carmen Ruggiero; Enzo Lalli
Journal:  Cancer Metastasis Rev       Date:  2021-01-20       Impact factor: 9.264

4.  The Correlation Between RhoA Expression and Clinicopathological Characteristics in Gastric Cancer Patients After Curative Surgery.

Authors:  Kuo-Hung Huang; Yuan-Tzu Lan; Ming-Huang Chen; Yee Chao; Su-Shun Lo; Anna Fen-Yau Li; Chew-Wun Wu; Shih-Hwa Chiou; Muh-Hwa Yang; Yi-Ming Shyr; Wen-Liang Fang
Journal:  World J Surg       Date:  2015-09       Impact factor: 3.352

Review 5.  The immune microenvironment in gastric adenocarcinoma.

Authors:  Yana Zavros; Juanita L Merchant
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2022-03-14       Impact factor: 73.082

Review 6.  Rho GTPases: Regulation and roles in cancer cell biology.

Authors:  Raquel B Haga; Anne J Ridley
Journal:  Small GTPases       Date:  2016-09-14

Review 7.  Emerging molecular basis of hematogenous metastasis in gastric cancer.

Authors:  Jing Zhong; Yan Chen; Liang-Jing Wang
Journal:  World J Gastroenterol       Date:  2016-02-28       Impact factor: 5.742

8.  The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice.

Authors:  Jone Garay; M Blanca Piazuelo; Sumana Majumdar; Li Li; Jimena Trillo-Tinoco; Luis Del Valle; Barbara G Schneider; Alberto G Delgado; Keith T Wilson; Pelayo Correa; Jovanny Zabaleta
Journal:  Cancer Lett       Date:  2015-11-27       Impact factor: 8.679

9.  Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.

Authors:  Ruirui Kong; Fengshuang Yi; Pushuai Wen; Jianghong Liu; Xiaoping Chen; Jinqi Ren; Xiaofei Li; Yulong Shang; Yongzhan Nie; Kaichun Wu; Daiming Fan; Li Zhu; Wei Feng; Jane Y Wu
Journal:  J Clin Invest       Date:  2015-11-03       Impact factor: 14.808

Review 10.  Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer.

Authors:  Byungho Lim; Jong-Hwan Kim; Mirang Kim; Seon-Young Kim
Journal:  World J Gastroenterol       Date:  2016-01-21       Impact factor: 5.742
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