BACKGROUND: Patients with autonomic failure may experience postural dizziness, syncope, and falls. Identifying symptomatic dysautonomia in dementia is of importance to ensure appropriate management and reduce risk of falls. OBJECTIVE: The aim of this prospective study is to identify cardiovascular autonomic dysfunction in patients suffering from behavioral variant of frontotemporal dementia (bvFTD), compared to Alzheimer's disease (AD). METHODS: Patients were prospectively recruited from 2009 until 2013. Clinical autonomic function tests were carried out in an Autonomic Unit according to Ewing's cardiovascular battery. Parasympathetic tests included resting heart rate variability, deep breathing, and Valsalva. Sympathetic function tests compromised blood pressure regulation on valsalva, cutaneous cold stimulation, and 70° head up tilt including of plasma noradrenaline. RESULTS: 26 patients (17 female) with bvFTD and 18 patients (10 female) with AD were examined. Mean age of bvFTD was 69 ± 11 years, AD 74 ± 9 years. History taking was often not conclusive and did not correlate with autonomic signs. In 42% bvFTD patients and 44% AD patients, autonomic dysfunction was demonstrated. Manifest orthostatic hypotension (OH) was present in 19% of bvFTD and 33% AD patients. Frequency of autonomic dysfunction and orthostatic hypotension did not differ between bvFTD and AD, but were significantly higher than in healthy controls. Autonomic dysfunction was associated with an increased risk of falling (assessed with Tinetti Score). CONCLUSION: This is the first prospective study to elucidate autonomic dysfunction in bvFTD patients. There is a considerable higher frequency of cardiovascular dysfunction and OH in bvFTD. History taking may be not conclusive thus cannot exclude cardiovascular dysautonomia.
BACKGROUND:Patients with autonomic failure may experience postural dizziness, syncope, and falls. Identifying symptomatic dysautonomia in dementia is of importance to ensure appropriate management and reduce risk of falls. OBJECTIVE: The aim of this prospective study is to identify cardiovascular autonomic dysfunction in patients suffering from behavioral variant of frontotemporal dementia (bvFTD), compared to Alzheimer's disease (AD). METHODS:Patients were prospectively recruited from 2009 until 2013. Clinical autonomic function tests were carried out in an Autonomic Unit according to Ewing's cardiovascular battery. Parasympathetic tests included resting heart rate variability, deep breathing, and Valsalva. Sympathetic function tests compromised blood pressure regulation on valsalva, cutaneous cold stimulation, and 70° head up tilt including of plasma noradrenaline. RESULTS: 26 patients (17 female) with bvFTD and 18 patients (10 female) with AD were examined. Mean age of bvFTD was 69 ± 11 years, AD 74 ± 9 years. History taking was often not conclusive and did not correlate with autonomic signs. In 42% bvFTD patients and 44% ADpatients, autonomic dysfunction was demonstrated. Manifest orthostatic hypotension (OH) was present in 19% of bvFTD and 33% ADpatients. Frequency of autonomic dysfunction and orthostatic hypotension did not differ between bvFTD and AD, but were significantly higher than in healthy controls. Autonomic dysfunction was associated with an increased risk of falling (assessed with Tinetti Score). CONCLUSION: This is the first prospective study to elucidate autonomic dysfunction in bvFTD patients. There is a considerable higher frequency of cardiovascular dysfunction and OH in bvFTD. History taking may be not conclusive thus cannot exclude cardiovascular dysautonomia.
Authors: Christine C Guo; Virginia E Sturm; Juan Zhou; Efstathios D Gennatas; Andrew J Trujillo; Alice Y Hua; Richard Crawford; Lara Stables; Joel H Kramer; Katherine Rankin; Robert W Levenson; Howard J Rosen; Bruce L Miller; William W Seeley Journal: Proc Natl Acad Sci U S A Date: 2016-04-11 Impact factor: 11.205
Authors: Rebekah M Ahmed; Sahar Latheef; Lauren Bartley; Muireann Irish; Glenda M Halliday; Matthew C Kiernan; John R Hodges; Olivier Piguet Journal: Neurology Date: 2015-09-16 Impact factor: 9.910
Authors: Phillip D Fletcher; Jennifer M Nicholas; Timothy J Shakespeare; Laura E Downey; Hannah L Golden; Jennifer L Agustus; Camilla N Clark; Catherine J Mummery; Jonathan M Schott; Sebastian J Crutch; Jason D Warren Journal: Front Behav Neurosci Date: 2015-03-24 Impact factor: 3.558
Authors: Charles R Marshall; Christopher J D Hardy; Micah Allen; Lucy L Russell; Camilla N Clark; Rebecca L Bond; Katrina M Dick; Emilie V Brotherhood; Jonathan D Rohrer; James M Kilner; Jason D Warren Journal: Ann Clin Transl Neurol Date: 2018-04-14 Impact factor: 4.511
Authors: Walter Struhal; Christoph Mahringer; Heinz Lahrmann; Christoph Mörtl; Peter Buhl; Mario Huemer; Gerhard Ransmayr Journal: J Alzheimers Dis Date: 2016-09-06 Impact factor: 4.472