Literature DB >> 2502429

Effects of iron-EDTA on uroporphyrinogen oxidation by liver microsomes.

J M Jacobs1, P R Sinclair, R W Lambrecht, J F Sinclair.   

Abstract

Uroporphyrinogen oxidation by hepatic microsomes from chick embryos or mice pretreated with methylcholanthrene was increased by addition of iron-EDTA. This increase was partially prevented by catalase, mannitol, ketoconazole and piperonyl butoxide, whereas only ketoconazole and piperonyl butoxide inhibited the oxidation in the presence and absence of iron-EDTA. These data suggest that the oxidations of uroporphyrinogen in the presence and absence of added iron occur by different mechanisms.

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Year:  1989        PMID： 2502429     DOI： 10.1016/0014-5793(89)80753-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

Review 1.  The role of transferrin in the mechanism of cellular iron uptake.

Authors:  K Thorstensen; I Romslo
Journal:  Biochem J       Date:  1990-10-01       Impact factor: 3.857

2.  Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation.

Authors:  R W Lambrecht; J M Jacobs; P R Sinclair; J F Sinclair
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

3.  Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C, and inherited uroporphyrinogen decarboxylase deficiency.

Authors:  Norman G Egger; Douglas E Goeger; Deborah A Payne; Emil P Miskovsky; Steven A Weinman; Karl E Anderson
Journal:  Dig Dis Sci       Date:  2002-02       Impact factor: 3.199

Review 4.  Uroporphyrinogen decarboxylase.

Authors:  G H Elder; A G Roberts
Journal:  J Bioenerg Biomembr       Date:  1995-04       Impact factor: 2.945
  4 in total

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