Literature DB >> 25023224

Using drug-intoxicated deaths as potential organ donors: impression of attendees at the American college of medical toxicology 2014 annual scientific meeting.

David M Wood1, Wui Ling Chan, Paul I Dargan.   

Abstract

INTRODUCTION: Over the last decade, there has been a reduction of organ donation from intracranial haemorrhage-, stroke- and blunt trauma-related deaths in the USA. There has been a corresponding increase in the use of drug-intoxicated patients as organ donors from 2.1 % in 2003 to 6.8 % in 2013.
METHODS: Questionnaire survey of attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting breakout session on transplantation from deaths related to poisoning was performed. Participants were asked whether they would recommend the use of solid organs from cocaine- or carbon monoxide-related death before and after the breakout session.
RESULTS: Forty-eight US participants (attending 23, fellow 15, resident 3 and other (including non-medical) 7) completed the survey, and 97.8 and 89.1 % of participants would consider cocaine- and carbon monoxide-related deaths for potential organ donation pre-breakout session, respectively; this increased to 100 % for both post-breakout sessions. There was variability in the consideration of different solid organs (the heart, lungs, liver, pancreas and kidneys)-76.2-95.2 and 76.2-85.7 % for individual solid organs for cocaine- and carbon monoxide-related deaths, respectively. For both scenarios, participants were least likely to consider potential heart donation (76.2 % of participants for both), which increased to 100 % following the breakout session.
CONCLUSIONS: Medical toxicologists have some reservation in recommending solid organs for transplantation from deaths from cocaine and carbon monoxide. Given the decrease in potential organ donors from typical methods of death, further work is needed to promote organ donation in deaths related to acute poisoning.

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Year:  2014        PMID: 25023224      PMCID: PMC4252283          DOI: 10.1007/s13181-014-0413-4

Source DB:  PubMed          Journal:  J Med Toxicol        ISSN: 1556-9039


  9 in total

1.  Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry.

Authors:  Andreas Brieke; Rajan Krishnamani; Michael J Rocha; Wenjun Li; Richard D Patten; Marvin A Konstam; Ayan R Patel; James E Udelson; David Denofrio
Journal:  J Heart Lung Transplant       Date:  2008-10-26       Impact factor: 10.247

2.  Donors with a history of cocaine use and lung transplant outcomes.

Authors:  Thomas J Lee; Matthew P Fox; Jaimin Trivedi; Victor van Berkel
Journal:  J Heart Lung Transplant       Date:  2012-08-23       Impact factor: 10.247

Review 3.  Improved outcome with organs from carbon monoxide poisoned donors for intrathoracic transplantation.

Authors:  H Luckraz; S S Tsui; J Parameshwar; J Wallwork; S R Large
Journal:  Ann Thorac Surg       Date:  2001-09       Impact factor: 4.330

Review 4.  Solid organ procurement from donors with carbon monoxide poisoning and/or burn--a systematic review.

Authors:  Marc N Busche; Karsten Knobloch; Christian Herold; Robert Krämer; Peter M Vogt; Hans-Oliver Rennekampff
Journal:  Burns       Date:  2011-03-06       Impact factor: 2.744

Review 5.  [Acute poisonings and organ donation--case reports and literature review].

Authors:  Dorota Klimaszyk; Magdalena Łukasik-Głebocka
Journal:  Przegl Lek       Date:  2013

Review 6.  Extended criteria for organ acceptance. Strategies for achieving organ safety and for increasing organ pool.

Authors:  Antonio López-Navidad; Francisco Caballero
Journal:  Clin Transplant       Date:  2003-08       Impact factor: 2.863

7.  Impact of donor high-risk social behaviors on recipient survival in cardiac transplantation.

Authors:  David S Xu; Deanna Hartman; Kristin Ludrosky; James Campbell; Randall C Starling; David O Taylor; Nicholas G Smedira; Gonzalo V Gonzalez-Stawinski
Journal:  Transplantation       Date:  2010-04-15       Impact factor: 4.939

Review 8.  Outcome following organ removal from poisoned donors in brain death status: a report of 12 cases and review of the literature.

Authors:  P Hantson; P Mahieu; A Hassoun; J B Otte
Journal:  J Toxicol Clin Toxicol       Date:  1995

9.  Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units.

Authors:  David Michael Wood; Paul Ivor Dargan; Alison Linda Jones
Journal:  Crit Care       Date:  2003-03-06       Impact factor: 9.097

  9 in total
  3 in total

Review 1.  Pesticide-Poisoned Patients: Can They Be Used as Potential Organ Donors?

Authors:  Umesh Mistry; Paul I Dargan; David M Wood
Journal:  J Med Toxicol       Date:  2018-07-09

Review 2.  Carbon monoxide: An emerging therapy for acute kidney injury.

Authors:  Xiaoxiao Yang; Mark de Caestecker; Leo E Otterbein; Binghe Wang
Journal:  Med Res Rev       Date:  2019-12-09       Impact factor: 12.944

3.  Successful Multiorgan Donation From a Brain-dead Donor Following Liquid Nicotine Voluntary Intoxication: A Case Report.

Authors:  Ana M Domínguez-Berrot; Myriam González-Vaquero; Antonio Sánchez-Vallejo
Journal:  Transplant Direct       Date:  2021-05-18
  3 in total

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