Audrey Gabelle1, Susanna Schraen2, Laure-Anne Gutierrez3, Cecile Pays3, Olivier Rouaud4, Luc Buée2, Jacques Touchon3, Catherine Helmer5, Jean-Charles Lambert6, Claudine Berr7. 1. Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; University Montpellier 1, Montpellier, France. 2. Université Droit et Santé de Lille, Lille, France; CHRU de Lille, Lille, France; INSERM UMR837, Lille, France. 3. Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; INSERM U1061, Hôpital La Colombière, Montpellier, France. 4. Department of Neurology, Centre Mémoire Ressources Recherche, CHRU Dijon, Dijon, France. 5. INSERM 897, ISPED, Victor Segalen University, Bordeaux, France. 6. CHRU de Lille, Lille, France; INSERM U744, Lille, France; Institut Pasteur de Lille, Lille, France; Université de Lille Nord de France, Lille, France. 7. Department of Neurology, Centre Mémoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France; INSERM U1061, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier, France. Electronic address: claudine.berr@inserm.fr.
Abstract
BACKGROUND: We evaluated if plasma β-amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study. METHODS: Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators. RESULTS: A relationship between high plasma Aβ1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01-1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels. CONCLUSIONS: Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.
BACKGROUND: We evaluated if plasma β-amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study. METHODS: Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators. RESULTS: A relationship between high plasma Aβ1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01-1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels. CONCLUSIONS: Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.
Authors: E S Epel; E Puterman; J Lin; E H Blackburn; P Y Lum; N D Beckmann; J Zhu; E Lee; A Gilbert; R A Rissman; R E Tanzi; E E Schadt Journal: Transl Psychiatry Date: 2016-08-30 Impact factor: 6.222