Susan K Mathai1, David A Schwartz, Laura A Warg. 1. aUniversity of Colorado Denver, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Aurora bNational Jewish Health, Denver cUniversity of Colorado Denver, Medical Scientist Training Program, Aurora, Colorado, USA.
Abstract
PURPOSE OF REVIEW: Recent genetic findings have identified new targets of investigation in the field of pulmonary fibrosis and have the potential to change clinical care. RECENT FINDINGS: These findings implicate alterations in host defense, cell-to-cell adhesion, and aging and senescence in the pathophysiology of pulmonary fibrosis. At least one common genetic variant strongly associated with pulmonary fibrosis appears to have prognostic implications for patients. SUMMARY: The inherited risk for pulmonary fibrosis is substantial, and recent data suggest that genetic risk for familial and sporadic forms of the disease are similar. Further characterizing this genetic risk will influence clinical practice in terms of categorization, diagnosis, and screening of individuals for this disease.
PURPOSE OF REVIEW: Recent genetic findings have identified new targets of investigation in the field of pulmonary fibrosis and have the potential to change clinical care. RECENT FINDINGS: These findings implicate alterations in host defense, cell-to-cell adhesion, and aging and senescence in the pathophysiology of pulmonary fibrosis. At least one common genetic variant strongly associated with pulmonary fibrosis appears to have prognostic implications for patients. SUMMARY: The inherited risk for pulmonary fibrosis is substantial, and recent data suggest that genetic risk for familial and sporadic forms of the disease are similar. Further characterizing this genetic risk will influence clinical practice in terms of categorization, diagnosis, and screening of individuals for this disease.
Authors: Beata Hutyrová; Panagiotis Pantelidis; Jirí Drábek; Monika Zůrková; Vítezslav Kolek; Karel Lenhart; Kenneth I Welsh; Roland M Du Bois; Martin Petrek Journal: Am J Respir Crit Care Med Date: 2002-01-15 Impact factor: 21.405
Authors: Tianju Liu; Matthew Ullenbruch; Yoon Young Choi; Hongfeng Yu; Lin Ding; Antoni Xaubet; Javier Pereda; Carol A Feghali-Bostwick; Peter B Bitterman; Craig A Henke; Annie Pardo; Moises Selman; Sem H Phan Journal: Am J Respir Cell Mol Biol Date: 2013-08 Impact factor: 6.914
Authors: Jonathan K Alder; Joy D Cogan; Andrew F Brown; Collin J Anderson; William E Lawson; Peter M Lansdorp; John A Phillips; James E Loyd; Julian J-L Chen; Mary Armanios Journal: PLoS Genet Date: 2011-03-31 Impact factor: 5.917
Authors: Christopher M Evans; Tasha E Fingerlin; Marvin I Schwarz; David Lynch; Jonathan Kurche; Laura Warg; Ivana V Yang; David A Schwartz Journal: Physiol Rev Date: 2016-10 Impact factor: 37.312
Authors: Chang-Min Lee; Soo Jung Cho; Won-Kyung Cho; Jin Wook Park; Jae-Hyun Lee; Augustine M Choi; Ivan O Rosas; Ming Zheng; Gary Peltz; Chun Geun Lee; Jack A Elias Journal: JCI Insight Date: 2018-09-20
Authors: Daryle J DePianto; Jason A Vander Heiden; Katrina B Morshead; Kai-Hui Sun; Zora Modrusan; Grace Teng; Paul J Wolters; Joseph R Arron Journal: JCI Insight Date: 2021-04-22