Ladislav Kočan1, Janka Vašková2, Ladislav Vaško3, Jana Simonová1, Róbert Simon4, Jozef Firment1. 1. 1st Clinic of Anaesthesiology and Intensive Care Medicine, Louis Pasteur University Hospital in Košice, Slovak Republic. 2. Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Slovak Republic. Electronic address: janka.vaskova@upjs.sk. 3. Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Slovak Republic. 4. 2nd Clinic of Surgery, Louis Pasteur University Hospital in Košice, Slovak Republic.
Abstract
OBJECTIVES: The objective of this paper is to highlight the selected group of patients in which adjuvant therapy seems to have a more pronounced positive effect. DESIGN AND METHODS: 65 septic patients from the prospective observational study Se-AOX (2008-2012) (ClinicalTrials.gov Identifier: NCT02026856) were divided into a Se group, receiving sodium selenite in a continual infusion of 750μg/24h for 6 days, and a placebo group. They were subsequently divided into subgroups according to the initial Carrico index (CI) on the day of admission: CI>200 and CI<200. Dynamical changes in glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase activities were recorded at two day intervals. Clinical parameters and mortality were compared. RESULTS: The CI increased in subgroup Se-CI<200 with negative correlation against subgroup Placebo-CI<200 during the last measuring period (p<0.02). GPx activity increased in selenium subgroups with negative correlation against placebo subgroups (p<0.01). SOD activity was elevated in all subgroups in comparison with values of healthy subjects. CONCLUSIONS: Adjuvant selenium therapy seems to be beneficial for a selected group of patients with acute lung injury. However, as is clear from the results discussed, this is not the case with persistent renal failure, as this leads to an inability to maintain synthetic renal function and ensure GPx synthesis.
OBJECTIVES: The objective of this paper is to highlight the selected group of patients in which adjuvant therapy seems to have a more pronounced positive effect. DESIGN AND METHODS: 65 septic patients from the prospective observational study Se-AOX (2008-2012) (ClinicalTrials.gov Identifier: NCT02026856) were divided into a Se group, receiving sodium selenite in a continual infusion of 750μg/24h for 6 days, and a placebo group. They were subsequently divided into subgroups according to the initial Carrico index (CI) on the day of admission: CI>200 and CI<200. Dynamical changes in glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase activities were recorded at two day intervals. Clinical parameters and mortality were compared. RESULTS: The CI increased in subgroup Se-CI<200 with negative correlation against subgroup Placebo-CI<200 during the last measuring period (p<0.02). GPx activity increased in selenium subgroups with negative correlation against placebo subgroups (p<0.01). SOD activity was elevated in all subgroups in comparison with values of healthy subjects. CONCLUSIONS: Adjuvant selenium therapy seems to be beneficial for a selected group of patients with acute lung injury. However, as is clear from the results discussed, this is not the case with persistent renal failure, as this leads to an inability to maintain synthetic renal function and ensure GPx synthesis.
Authors: Rachel L Markley; Katherine H Restori; Bhuvana Katkere; Sarah E Sumner; McKayla J Nicol; Anastasia Tyryshkina; Shaneice K Nettleford; David R Williamson; David E Place; Kalyan K Dewan; Ashley E Shay; Bradley A Carlson; Santhosh Girirajan; K Sandeep Prabhu; Girish S Kirimanjeswara Journal: Front Immunol Date: 2021-10-29 Impact factor: 8.786
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