Literature DB >> 25019996

An unconventional BST-2 function: down-regulation of transient protein expression.

Jaraspim Narkpuk1, Asawin Wanitchang1, Jarin Kramyu1, Phanramphoei Namprachan Frantz1, Anan Jongkaewwattana1, Samaporn Teeravechyan2.   

Abstract

While viral inhibition by tethering of budding virions to host cell membranes has been focused upon as one of the main functions of BST-2/tetherin, BST-2 is thought to possess other functions as well. Overexpression of BST-2 was found here to down-regulate transient protein expression. Removal of the N- and C-terminal regions of BST-2, previously described to be involved in signal transduction, reduced the impact of BST-2. These results suggest that BST-2-mediated signaling may play a role in regulating the levels of transiently expressed proteins, highlighting a new function for BST-2 that may also have implications for viral inhibition.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  BST-2; Influenza virus; Protein expression; Reverse genetics; Tetherin

Mesh：

Substances：

Year:  2014        PMID： 25019996     DOI： 10.1016/j.bbrc.2014.07.022

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus.

Authors:  Lemme P Kebaabetswe; Anoria K Haick; Marina A Gritsenko; Thomas L Fillmore; Rosalie K Chu; Samuel O Purvine; Bobbie-Jo Webb-Robertson; Melissa M Matzke; Richard D Smith; Katrina M Waters; Thomas O Metz; Tanya A Miura
Journal:  Virology       Date:  2015-05-15       Impact factor: 3.616

2.  Murine BST2/tetherin promotes measles virus infection of neurons.

Authors:  Katelyn D Miller; Christine Matullo; Riley Williams; Carli B Jones; Glenn F Rall
Journal:  Virology       Date:  2021-08-15       Impact factor: 3.616

3.  BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection.

Authors:  Shuzo Urata; Elizabeth Kenyon; Debasis Nayak; Beatrice Cubitt; Yohei Kurosaki; Jiro Yasuda; Juan C de la Torre; Dorian B McGavern
Journal:  PLoS Pathog       Date:  2018-07-20       Impact factor: 6.823

4.  BST2/Tetherin Overexpression Modulates Morbillivirus Glycoprotein Production to Inhibit Cell-Cell Fusion.

Authors:  James T Kelly; Stacey Human; Joseph Alderman; Fatoumatta Jobe; Leanne Logan; Thomas Rix; Daniel Gonçalves-Carneiro; Corwin Leung; Nazia Thakur; Jamie Birch; Dalan Bailey
Journal:  Viruses       Date:  2019-07-30       Impact factor: 5.048

5.  The impact of bone marrow stromal antigen-2 (BST2) gene variants on HIV-1 control in black South African individuals.

Authors:  Bianca Da Costa Dias; Maria Paximadis; Neil Martinson; Richard E Chaisson; Osman Ebrahim; Caroline T Tiemessen
Journal:  Infect Genet Evol       Date:  2020-01-30       Impact factor: 3.342

6.  The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin.

Authors:  Jaraspim Narkpuk; Anan Jongkaewwattana; Samaporn Teeravechyan
Journal:  Virology       Date:  2018-10-02       Impact factor: 3.616
  6 in total

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