Literature DB >> 25019221

ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.

Weicang Wang1, Julia Zhu1, Fei Lyu1, Dipak Panigrahy2, Katherine W Ferrara3, Bruce Hammock4, Guodong Zhang5.   

Abstract

Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of ω-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which ω-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The ω-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived ω-3-series lipid metabolites on angiogenesis, inflammation and cancer.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cyclooxygenase; Cytochrome P450; Lipoxygenase; ω-3 polyunsaturated fatty acids

Mesh：

Substances：

Year:  2014        PMID： 25019221      PMCID： PMC4306447          DOI： 10.1016/j.prostaglandins.2014.07.002

Source DB:  PubMed          Journal:  Prostaglandins Other Lipid Mediat        ISSN： 1098-8823            Impact factor:   3.072


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